Abstract
Nonsmall-cell lung cancer is a severe disease with high morbidity and mortality. However, the systemic administration of anticancer drugs generally leads to serious toxicity and low anti-lung cancer efficiency because of very limited drug distribution in the lung. In our previous research, we have confirmed the high anti-lung cancer effect of inhalable oridonin microparticles in spite of their long and complicated preparation process. Here, we develop a novel, simple, and quick method for preparing inhalable oridonin-loaded poly(d,l-lactic-co-glycolic)acid (PLGA) porous microspheres using the electrospraying technique. The formulation and preparation processes were screened. The electrospraying porous microspheres (EPMs) were rough, porous, and suitable for pulmonary delivery. Most of the oridonin was released from the EPMs within 20 h based on drug diffusion and via PLGA erosion. The EPMs exhibited efficient lung deposition in vitro and in vivo because of their ideal aerodynamic diameters. Chemical carcinogens were used to prepare primary lung cancer rat models by direct pulmonary delivery. The EPMs showed high anti-lung cancer effect after pulmonary delivery according to CT images and pathology. Inhibition of angiogenesis and...Continue Reading
References
Jun 20, 1997·Science·D A EdwardsR Langer
Apr 10, 2002·American Journal of Physiology. Cell Physiology·Michael Papetti, Ira M Herman
Aug 3, 2005·Cancer Research·Yiwei LiFazlul H Sarkar
Jan 2, 2007·Blood·Guang-Biao ZhouZhu Chen
Apr 26, 2008·Biomaterials·Ching-Li TsengMing-Jium Shieh
Jun 18, 2010·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jangwook LeeKuen Yong Lee
Oct 26, 2010·Biochemical and Biophysical Research Communications·Wen-bin LiuJin-yi Liu
Apr 9, 2013·Journal of Controlled Release : Official Journal of the Controlled Release Society·Devender S DhandaUday B Kompella
May 9, 2013·Current Pharmaceutical Design·Adam BohrMingshi Yang
Sep 26, 2013·Pharmaceutical Research·Xueqin GuoXiaohong Li
Apr 9, 2015·Scientia pharmaceutica·Aliasgar KundawalaDhaglaram Choudhary
Apr 29, 2015·Expert Opinion on Drug Delivery·Wing-Hin LeePaul M Young
Jul 3, 2015·Small·Caina XuXuesi Chen
Sep 30, 2015·Advanced Drug Delivery Reviews·Praveena JayaramanDinesh Kumar Srinivasan
Aug 16, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tian LuoRita Vanbever
Nov 5, 2016·International Journal of Pharmaceutics·Vincent LevetNathalie Wauthoz
Nov 21, 2016·International Journal of Pharmaceutics·Tatsuaki TagamiTetsuya Ozeki
Jan 26, 2017·Acta Pharmaceutica Sinica. B·Lifei ZhuYiguang Jin
Feb 10, 2017·Anticancer Research·Hind RafeiImad Tabbara
May 7, 2013·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Jun-Bing FanShutao Wang
Citations
Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanyuan ZhangHuagang Sheng
May 21, 2019·Frontiers in Chemistry·Jiamian WangFang Yang
Jan 27, 2021·Pharmaceutics·Yuyoung Kim, Hongkee Sah
Nov 6, 2020·Regenerative Biomaterials·Yuzhu HeXiumei Wang
Jan 22, 2019·Journal of Aerosol Science·Sunil Kumar BodaJingwei Xie
Nov 20, 2020·Drug Discovery Today·Ranjita Misra, Sarbari Acharya
May 7, 2021·Advanced Drug Delivery Reviews·Amna AliZeeshan Ahmad
Feb 11, 2019·ACS Biomaterials Science & Engineering·Xiaodong SunYiguang Jin
Mar 3, 2020·ACS Omega·Hao PhamFangyuan Tian
Feb 13, 2018·Ultrasonics Sonochemistry·Reza AbazariCameron L Carpenter-Warren