Drug-Loaded PLGA Electrospraying Porous Microspheres for the Local Therapy of Primary Lung Cancer via Pulmonary Delivery

ACS Omega
Lifei ZhuYiguang Jin

Abstract

Nonsmall-cell lung cancer is a severe disease with high morbidity and mortality. However, the systemic administration of anticancer drugs generally leads to serious toxicity and low anti-lung cancer efficiency because of very limited drug distribution in the lung. In our previous research, we have confirmed the high anti-lung cancer effect of inhalable oridonin microparticles in spite of their long and complicated preparation process. Here, we develop a novel, simple, and quick method for preparing inhalable oridonin-loaded poly(d,l-lactic-co-glycolic)acid (PLGA) porous microspheres using the electrospraying technique. The formulation and preparation processes were screened. The electrospraying porous microspheres (EPMs) were rough, porous, and suitable for pulmonary delivery. Most of the oridonin was released from the EPMs within 20 h based on drug diffusion and via PLGA erosion. The EPMs exhibited efficient lung deposition in vitro and in vivo because of their ideal aerodynamic diameters. Chemical carcinogens were used to prepare primary lung cancer rat models by direct pulmonary delivery. The EPMs showed high anti-lung cancer effect after pulmonary delivery according to CT images and pathology. Inhibition of angiogenesis and...Continue Reading

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Citations

Jan 18, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yuanyuan ZhangHuagang Sheng
Jan 27, 2021·Pharmaceutics·Yuyoung Kim, Hongkee Sah
Jan 22, 2019·Journal of Aerosol Science·Sunil Kumar BodaJingwei Xie
Nov 20, 2020·Drug Discovery Today·Ranjita Misra, Sarbari Acharya

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Methods Mentioned

BETA
scanning electron microscopy
light scattering
X-ray
differential scanning calorimetry
fluorescence microscopy

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