Drug loading of foldable commercial intraocular lenses using supercritical impregnation

International Journal of Pharmaceutics
A BouledjouidjaE Badens

Abstract

The drug delivery through intraocular lenses (IOLs) allows the combination of cataract surgery act and postoperative treatment in a single procedure. In order to prepare such systems, "clean" supercritical CO2 processes are studied for loading commercial IOLs with ophthalmic drugs. Ciprofloxacin (CIP, an antibiotic) and dexamethasone 21-phosphate disodium (DXP, an anti-inflammatory drug) were impregnated into foldable IOLs made from poly-2-hydroxyethyl methacrylate (P-HEMA). A first pre-treatment step was conducted in order to remove absorbed conditioning physiological solution. Supercritical impregnations were then performed by varying the experimental conditions. In order to obtain transparent IOLs and avoid the appearance of undesirable foaming, it was necessary to couple slow pressurization and depressurization phases during supercritical treatments. The impregnation yields were determined through drug release studies. For both drugs, release studies show deep and reproducible impregnation for different diopters. For the system P-HEMA/CIP, a series of impregnations was performed to delimit the experimental range at two pressures (80 and 200 bar) in the presence or absence of ethanol as a co-solvent for two diopters (+5.0 D ...Continue Reading

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Citations

Jul 29, 2017·Advanced Healthcare Materials·Ranjith Kumar KankalaAi-Zheng Chen
Nov 10, 2017·Journal of Cataract and Refractive Surgery·Abir BouledjouidjaElisabeth Badens
Oct 31, 2017·Biomedical Optics Express·José M ArtigasEduardo Fernández
Jan 1, 2021·Pharmaceutics·N ToffolettoA P Serro
Apr 10, 2019·IET Nanobiotechnology·Lampros LamprogiannisStergios Logothetidis
Apr 4, 2021·Polymers·Paola Franco, Iolanda De Marco
Mar 1, 2020·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Kanjana OngkasinElisabeth Badens
Apr 19, 2021·International Journal of Pharmaceutics·Ana TopeteAna Paula Serro
Sep 26, 2020·Progress in Retinal and Eye Research·I M WormstoneJ A Eldred

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