Drug localizations in tissue by mass spectrometry imaging

Biomarkers in Medicine
Ákos Végvári

Abstract

Advances in development of mass spectrometry (MS) are successfully utilized for spatial localization of pharmaceutical compounds in these tissue sections. Today MS instruments can be used in imaging mode when the datasets are generated from the surface of the tissue over an array of acquisition positions. This review is focused on the technological developments of matrix-assisted laser desorption/ionization MS imaging (MALDI-MSI) and related sample preparation procedures. MALDI-MSI provides a sensitive and label-free approach for imaging of drugs and their metabolites. Due to these features, MALDI-MSI is expected to become a standard technique in pharmaceutical development providing complementary information to current methods.

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Citations

Mar 12, 2016·Clinical and Translational Medicine·Ákos VégváriGyörgy Marko-Varga
May 28, 2019·International Journal of Molecular Sciences·Cristina Alexandra Ciocan-CartitaIoana Berindan-Neagoe
Jan 21, 2020·Expert Review of Clinical Pharmacology·Michele MussapVassilios Fanos
Jun 6, 2020·Mass Spectrometry Reviews·Enrico DavoliLavinia Morosi

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Methods Mentioned

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biopsies
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Software Mentioned

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MSImaging
imzML

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