Drug-mediated and cellular immunotherapy in multiple myeloma

Immunotherapy
David S RitchiePaul Neeson

Abstract

Multiple myeloma is an immunologically relevant disease, which subverts and suppresses immunity, but that may also be amenable to immunological control. Novel drug and cell-based therapies provide an opportunity for the design of antimyeloma immunotherapy. Reversing the immunosuppression associated myeloma remains a substantial challenge. The minimal residual disease setting achieved by autologous stem cell transplant or highly efficacious induction therapy may reverse this immunoparesis and provide a setting for induction of antimyeloma T-cell responses. Adoptive cytotoxic T-lymphocyte/NK therapy and comprehensive treatment with immunomodulatory drug therapy represent means by which antimyeloma immune responses may be promoted. In addition, apoptosis-inducing therapies may prime endogenous antigen presentation via immunogenic cell death, which again may be enhanced by the addition of immunomodulatory drug therapy.

References

Jun 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·G GahrtonP Jacobs
Aug 3, 1994·Journal of the National Cancer Institute·S A RosenbergD E White
Mar 23, 1996·Lancet·L F VerdonckE J Petersen
Feb 1, 1997·Hematology/oncology Clinics of North America·N C Munshi
Apr 13, 2000·European Journal of Immunology·G Eberl, H R MacDonald
Aug 16, 2000·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·H M LokhorstL F Verdonck
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·G EberlH R MacDonald
Dec 29, 2000·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·A LisoR Levy
Mar 29, 2001·Nature Immunology·M J SmythJ A Trapani
Sep 1, 2001·Clinical and Experimental Immunology·M A FrassanitoF Dammacco
May 8, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Keith DredgeAngus G Dalgleish
Aug 16, 2002·British Journal of Haematology·Chengyun ZhengAnne Sundblad
Nov 20, 2002·British Journal of Haematology·Christoph FrohnJürgen Luhm
Dec 31, 2002·Journal of Immunological Methods·Shin-ichiro FujiiMadhav V Dhodapkar
Mar 22, 2003·The Journal of Pharmacology and Experimental Therapeutics·Peter H SchaferDavid I Stirling
Apr 26, 2003·Blood·Toshiaki HayashiKenneth C Anderson
Jun 6, 2003·British Journal of Haematology·Britta MaeckerJoachim L Schultze
Jun 11, 2003·The Journal of Experimental Medicine·Madhav V DhodapkarJoseph Krasovsky
Sep 27, 2003·Blood·Richard LeBlancNikhil C Munshi
Jan 7, 2004·Nature Reviews. Drug Discovery·Michael KarinQ May Wang
Feb 11, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Haralambos Gavras
Apr 20, 2004·Blood·Teru HideshimaKenneth C Anderson
Jul 13, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Subramanya HegdeSigrun Smola-Hess
Aug 17, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Piotr TrzonkowskiAndrzej Myśliwski
Dec 21, 2004·Leukemia Research·Hatsue OgawaraHirokazu Murakami
Dec 30, 2004·Proceedings of the National Academy of Sciences of the United States of America·Mei-Ling ChenKhashayarsha Khazaie
Jan 11, 2005·British Journal of Haematology·Toshiaki HayashiKenneth C Anderson

❮ Previous
Next ❯

Citations

Dec 17, 2010·Investigational New Drugs·Michael DickinsonH Miles Prince
May 17, 2019·Journal of Oncology·Rachel E CookeDavid Ritchie

❮ Previous
Next ❯

Methods Mentioned

BETA
biopsies

Related Concepts

Related Feeds

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Cancer Vaccines

Cancer vaccines are vaccines that either treat existing cancer or prevent development of a cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.