Drug-mediated toxicity: illuminating the 'bad' in the test tube by means of cellular assays?

Trends in Pharmacological Sciences
Tewes Tralau, Andreas Luch

Abstract

Health problems are rising worldwide, be it as a consequence of lifestyle and longevity in increasingly affluent societies or due to a sharp rise in bacterial antibiotic resistance. The pharmaceutical industry is caught between high rates of attrition and the rather slow pace of a historically large regulatory system for pharmacological safety. Meanwhile, the past decade has seen a tremendous evolution of the biological toolbox, most notably of cellular assays, stem-cell differentiation and organ-mimicking systems. These systems were readily adapted for lead-compound identification. However, their use as toxicological test systems is lagging behind, not least because of a lack of regulatory acceptance. This review tries to elucidate the scale of the problem and discusses the applicability of the assays currently available, with particular regard to the use of stem cells.

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Citations

May 17, 2014·Nature Reviews. Drug Discovery·David CookMenelas N Pangalos
Aug 9, 2012·Environmental Health Perspectives·Tewes TralauAndreas Luch
Sep 14, 2012·Expert Opinion on Drug Metabolism & Toxicology·Tewes Tralau, Andreas Luch
Aug 15, 2013·Expert Opinion on Drug Metabolism & Toxicology·Tewes Tralau, Andreas Luch
Jul 28, 2016·Trends in Pharmacological Sciences·Josephine KuglerMichael Oelgeschläger
Jul 5, 2017·Expert Opinion on Drug Metabolism & Toxicology·Josephine KuglerAndreas Luch
Apr 18, 2019·Clinical Pharmacology and Therapeutics·Alexandre J S RibeiroDavid G Strauss
Jul 22, 2021·APL Bioengineering·Erika Ferrari, Marco Rasponi

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