Drug metabolizing activity in rats with chronic liver injury induced by carbon tetrachloride: relationship with the content of hydroxyproline in the liver

Japanese Journal of Pharmacology
H OkunoY Sameshima

Abstract

The drug metabolizing activity of rat liver during long-term administration of carbon tetrachloride (CCl4), and its relationship with the content of hydroxyproline (Hyp) in the liver were examined. The contents of cytochrome P-450 (P-450) and cytochrome b5 (b5) and the metabolization of aniline, aminopyrine, 7-ethoxycoumarin (7-EC) and benzo(a)pyrene (B(a)P) in the microsomal fraction were examined five days after the final administration of CCl4. The contents of P-450 and b5 and the activity to metabolize the four substrates were gradually reduced as the Hyp content in the liver increased. However, aminopyrine N-demethylation and B(a)P hydroxylation, particularly the latter, was more reduced than aniline hydroxylation and 7-EC O-deethylation in the early stage of hepatic fibrosis. Such differences may be due mainly to the different P-450 subtypes affected by CCl4.

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Citations

Jan 1, 2014·Antioxidants·Dharmendra SinghRadhey Shyam Gupta
Aug 21, 2012·International Immunopharmacology·Xiaochen QiuZhaofan Xia
Nov 28, 2009·Journal of Ethnopharmacology·Arumugam SomasundaramMuthu Raja
Apr 26, 2012·Inhalation Toxicology·Feng ZhuZhaofan Xia
Mar 19, 2013·International Immunopharmacology·Wuquan LiZhaofan Xia

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