Drug metabolizing function of isolated perfused liver.

Japanese Journal of Pharmacology
T NodaH Kaneto

Abstract

How closely the isolated liver of the rat would simulate the in vivo function of the organ in terms of the metabolic pattern of the compounds such as bromosulphophthalein, p-nitrophenol, hexobarbital, and indocyanine green was investigated. In order to produce tissue with the stimulated function, the animal was pretreated with phenobarbital and, for the reverse purpose, with ethionine. Some of the indices of the function employed herein, such as the appearance pattern of the compound, the rate of biochemical transformation or the biliary excretion, showed that the perfused liver would generally well reflect the in vivo situation. The method with isolated and perfused liver could exclude the participation of other organs and also the influence of the factors unavoidable in an in vivo experiment. Thus, it is suggested that the isolated perfused liver is useful for studying directly the functional level of the organ as drug metabolizing tissue.

References

Oct 1, 1971·Biochemical Pharmacology·E E OhnhausA Breckenridge
May 1, 1966·The Biochemical Journal·G A Tomlinson, S J Yaffe
Nov 1, 1966·The Biochemical Journal·R HemsH A Krebs
Mar 2, 1961·The New England Journal of Medicine·C L MENDENHALL, C M LEEVY
Apr 1, 1960·The Journal of Clinical Investigation·G R CHERRICKC S DAVIDSON

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Citations

Jan 1, 1989·Drug Metabolism and Drug Interactions·G M PowellC G Curtis
Dec 1, 1977·The Australian and New Zealand Journal of Surgery·D LeeA K Groufsky
Jan 1, 1979·Oecologia·R J Hnatiuk

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