Abstract
The monitoring of quinine by HPLC in 3 patients suffering from cerebral malaria with acute renal failure and treated by haemofiltration is reported. The recommended dose of quinine in this situation is reduced to 10 to 15 mg.kg-1.day-1. However, in the first patient, when given quinine 10 mg kg-1.day-1 the plasma concentration was mainly below the recommended therapeutic range of 5 to 15 mg/l. In consequence, the dose of quinine in the second patient was elevated to quinine dihydrochloride 15.1 mg.kg-1.day-1 which produced plasma concentrations in the low therapeutic range. In the third patient, an unreduced dose of quinine dihydrochloride 25.7 mg.kg-1.day-1 was employed, resulting in plasma concentrations above 15 mg/l, which is generally assumed to be toxic, although, no sign of acute quinine toxicity was seen. The antimalarial effect in all three patients was satisfactory. Quinine was estimated in the haemofiltrate in two patients and was found to be below the limit of sensitivity (0.25 mg/l). Plasma quinine did not change during or shortly after haemofiltration. It is concluded that in case of acute renal failure in cerebral malaria the dose of quinine should be reduced, but that the common recommendation of 10 to 15 mg.kg-...Continue Reading
References
Jul 15, 1976·Klinische Wochenschrift·M WeiseA Voller
Feb 7, 1976·British Medical Journal·A P Hall
Feb 16, 1985·Lancet·M E BolandJ A Henry
Mar 30, 1985·Lancet·J L GibbsP Sharpstone
Jun 22, 1985·Lancet·A Hall
Jul 1, 1985·The American Journal of Tropical Medicine and Hygiene·K SilamutD A Warrell
Jul 6, 1985·British Medical Journal·E H DysonR Heyworth
Oct 26, 1985·British Medical Journal·A HallA Marsh
Nov 8, 1985·Journal of Chromatography·S E TettK F Brown
Jan 28, 1967·Lancet·V SitprijaP Piyaratn
Aug 26, 1967·Lancet·H A ReidF K Wright
Feb 24, 1968·Lancet·J V DonadioL Kazyak
Apr 1, 1972·Archives of Internal Medicine·W J StoneJ H Knepshield
Sep 1, 1968·Archives of Internal Medicine·C J CanfieldK G Barry
Dec 1, 1968·The American Journal of Medicine·D C DukesJ I Forbes
Dec 9, 1983·Journal of Chromatography·M EdsteinF Shann
Oct 1, 1982·The American Journal of Medicine·N J WhiteT Harinasuta
Citations
Jan 1, 1989·European Journal of Clinical Pharmacology·A M SharmaK Borner
Aug 21, 1992·Pharmaceutisch Weekblad. Scientific Edition·C O OnyejiN C Ugwu
May 20, 2008·Intensive Care Medicine·Jérôme LiotierBertrand Souweine
Jan 12, 1991·Lancet·M G BrookB A Bannister
Aug 13, 2004·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·F JacobsF Brivet
Jan 1, 1990·The Journal of Pharmacy and Pharmacology·M D ColemanL Fleckenstein
Oct 24, 2006·Médecine et maladies infectieuses·R PetrognaniJ-M Saïssy
Aug 1, 2006·Rapid Communications in Mass Spectrometry : RCM·Richard DamienFrançois Coudoré
May 12, 2009·Angewandte Chemie·Steven K TaylorMilan N Stojanovic
Feb 28, 2013·Chemical Communications : Chem Comm·Aliaa I ShallanMichael C Breadmore
May 1, 1996·The Annals of Pharmacotherapy·J G DaviesM K Street
Sep 24, 2020·Journal of the American Society of Nephrology : JASN·Ingrid BerlingUNKNOWN EXTRIP workgroup