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Drug-nucleic acid interaction: X-ray crystallographic determination of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-iodouridylyl(3'-5')adenosine

Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

Nov 6, 1975

C C TsaiHenry M Sobell

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Abstract

The intercalative trypanosomal drug, ethidium bromide, forms a crystalline complex with the dinucleoside monophosphate, 5-iodiuridylyl(3'-5')adenosine (iodoUpA). These crystals are monoclinic, space group C2, with unit cell dimensions, a = 2.845 nm, b = 1.354 nm, c = 3.413 nm, beta = 98...read more

Mentioned in this Paper

Small Molecule
Antigen I(2), Trypanosome
Models, Structural
Helix (Snails)
Radiographic Imaging Procedure
Dinucleoside Phosphates
Crystal - Body Material
Study
X-Ray Diffraction
Symmetry
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  • Drug-nucleic acid interaction: X-ray crystallographic determination of an ethidium-dinucleoside monophosphate crystalline complex, ethidium: 5-iodouridylyl(3'-5')adenosine

    Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences

    Nov 6, 1975

    C C TsaiHenry M Sobell

    PMID: 1810

    DOI: 10.1098/rstb.1975.0076

    Abstract

    The intercalative trypanosomal drug, ethidium bromide, forms a crystalline complex with the dinucleoside monophosphate, 5-iodiuridylyl(3'-5')adenosine (iodoUpA). These crystals are monoclinic, space group C2, with unit cell dimensions, a = 2.845 nm, b = 1.354 nm, c = 3.413 nm, beta = 98...read more

    Mentioned in this Paper

    Small Molecule
    Antigen I(2), Trypanosome
    Models, Structural
    Helix (Snails)
    Radiographic Imaging Procedure

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