Drug plasma levels and platelet 5-HT uptake inhibition during long-term treatment with fluvoxamine or lithium in patients with affective disorders

British Journal of Clinical Pharmacology
K WoodA Coppen

Abstract

1 Plasma levels and platelet 5-HT uptake characteristics were determined at baseline and at various times during a long-term study comparing fluvoxamine and lithium prophylaxis. 2 In the fluvoxamine-treated patients after 12 and 24 weeks of treatment, Km was significantly increased and y, the mean overall uptake, significantly decreased compared to the patients' own baseline values and to lithium treatment. No significant change was noted for Vmax. 3 For fluvoxamine, significant negative relationships were established between the Vmax of platelet 5-HT uptake and plasma levels. 4 The trial had to be discontinued prematurely for some patients due to apparent lack of efficacy, unwanted effects or a combination of both in the fluvoxamine-treated patients. Low plasma levels of fluvoxamine may have contributed to the apparent lack of prophylactic efficacy of the drug. 5 Reference is made to the activity of receptor systems in patients receiving lithium and the consequent changes occurring after the administration of a potent 5-HT re-uptake inhibitor.

References

Aug 1, 1977·British Journal of Pharmacology·V ClaassenP Placheta
Jul 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenA Jorgensen
Sep 1, 1978·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenM Peet
May 1, 1976·The British Journal of Psychiatry : the Journal of Mental Science·A CoppenJ E Bailey
May 1, 1976·Pharmakopsychiatrie, Neuro-Psychopharmakologie·E S PaykelM M Weissman

❮ Previous
Next ❯

Citations

Jan 1, 1995·Journal of Neural Transmission. General Section·W PirkerT Brücke
Aug 23, 1991·Pharmaceutisch Weekblad. Scientific Edition·A J LoonenG J Zwanikken
Aug 24, 1990·Pharmaceutisch Weekblad. Scientific Edition·A J Loonen, G J Zwanikken
Dec 1, 1984·Journal of Affective Disorders·K R NortonE S Paykel
Dec 1, 1984·Journal of Affective Disorders·A CoppenM J Mitchell
Oct 1, 1994·Journal of Affective Disorders·P GrofM Walsh
Feb 15, 1988·Experientia·A Wirz-Justice
Jul 18, 2015·International Journal of Bipolar Disorders·U LewitzkaM Bauer
Nov 23, 2007·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Osama M AhmedR G Ahmed

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

The British Journal of Psychiatry : the Journal of Mental Science
J Snowdon
Acta Psychiatrica Scandinavica
G N Christodoulou, E P Lykouras
© 2021 Meta ULC. All rights reserved