Drug prescribing during pregnancy in a central region of Italy, 2008-2012

BMC Public Health
Martina VenturaSerena Donati

Abstract

Drug consumption during pregnancy is a matter of concern, especially regarding drugs known or suspected to be teratogens. Little is known about drug use in pregnant women in Italy. The present study is aimed at examining the prevalence, and to detect potential inappropriateness of drug prescribing among pregnant women in Latium, a region of central Italy. This retrospective study was conducted on a cohort of women aged 18-45 years who delivered between 2008 and 2012 in public hospitals. Women were enrolled through the Regional Birth Register. After linking the regional Health Information Systems and the Regional Drug Claims Register, women's clinical data and prescribed medications were analyzed. Italian Medicine Agency (AIFA) and US Food and Drug Administration (FDA) evidence were used to investigate inappropriate prescribing and teratogenic risk. Excluding vitamins and minerals, 80.6% (n = 153,079) of the women were prescribed at least one drug during pregnancy, with an average of 4.6 medications per pregnancy. Drugs for blood and hematopoietic organs were the most commonly prescribed (53.0%,), followed by anti-infectives for systemic use (50.7%). Among the inappropriate prescriptions, progestogen supplementation was given in...Continue Reading

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Citations

Jun 3, 2020·International Journal of Environmental Research and Public Health·Angela LupattelliHedvig Nordeng
Nov 22, 2019·Pharmacoepidemiology and Drug Safety·Sara Sanchez OrtizLucía Cea Soriano
Jun 30, 2019·F1000Research·Sarah Je Stock, Jane E Norman
Nov 18, 2020·British Journal of Clinical Pharmacology·Dongmei SunFacundo Garcia-Bournissen
Feb 12, 2021·BMJ : British Medical Journal·Niklas Worm AnderssonJon Trærup Andersen
Sep 10, 2021·Pharmacoepidemiology and Drug Safety·Andrea V MargulisElena Rivero-Ferrer

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