journal cover

Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin

Biochemistry

Jan 1, 1985

Thomas J LukasDaniel Martin Watterson

PMID: 3994963

Get paper from

Abstract

Phenoxybenzamine, an alpha-adrenergic antagonist containing a (chloroethyl)amine group, labels calmodulin in the presence of calcium. The covalent interaction is inhibited by chlorpromazine in a concentration-dependent manner. Adducts of calmodulin and phenoxybenzamine were separated by...read more

Mentioned in this Paper

CNP gene
alpha-Adrenergic Blocker [EPC]
Myosin Light Chain Kinase
Calmodulin 1
Covalent Interaction
Calcium [EPC]
Drug Binding
Tritium
Chlorpromazine
Brain
Paper Details
References
  • References15
  • Citations15
12
  • References15
  • Citations15
12

Drug-protein interactions: isolation and characterization of covalent adducts of phenoxybenzamine and calmodulin

Biochemistry

Jan 1, 1985

Thomas J LukasDaniel Martin Watterson

PMID: 3994963

DOI:

Abstract

Phenoxybenzamine, an alpha-adrenergic antagonist containing a (chloroethyl)amine group, labels calmodulin in the presence of calcium. The covalent interaction is inhibited by chlorpromazine in a concentration-dependent manner. Adducts of calmodulin and phenoxybenzamine were separated by...read more

Mentioned in this Paper

CNP gene
alpha-Adrenergic Blocker [EPC]
Myosin Light Chain Kinase
Calmodulin 1
Covalent Interaction

Related Papers

Paper Details
References
  • References15
  • Citations15
12
  • References15
  • Citations15
12

Get paper from

/papers/drug-protein-interactions-isolation-and/3994963