Drug-/radiation-induced interstitial lung disease in the United Kingdom general population: incidence, all-cause mortality and characteristics at diagnosis

Respirology : Official Journal of the Asian Pacific Society of Respirology
Rajeev K AmarChristoph R Meier

Abstract

Radiotherapy and an increasing number of substances are implicated in the pathogenesis of interstitial lung disease (ILD). While the frequency of published data on more common ILD entities such as the idiopathic interstitial pneumonias has increased in recent years, less attention has been given to relatively rarely occurring forms such as drug-/radiation-induced ILD. Data from the UK-based General Practice Research Database (GPRD) was used to estimate the incidence of drug-/radiation-induced ILD over a 12-year period (1997-2008). Crude incidence rates were stratified by gender, age group and calendar period, and rate ratios were adjusted using Poisson regression. All-cause mortality was modelled using Cox regression, and characteristics at diagnosis were compared with a random sample of matched, non-ILD controls using conditional logistic regression. A total of 128 patients with an incident diagnosis of drug-/radiation-induced ILD were identified, and the overall incidence density during the study period was 4.1 (95% confidence interval 3.4-4.9) per million person-years. Incidence rates increased during the time period 1997-2005 and decreased thereafter. The adjusted all-cause mortality was >4 times higher in cases compared wi...Continue Reading

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Citations

Oct 30, 2012·Immunology and Allergy Clinics of North America·Toby M Maher
Jan 23, 2013·Respirology : Official Journal of the Asian Pacific Society of Respirology·Neil D EvesToby M Maher
Jan 30, 2013·Pharmacoepidemiology and Drug Safety·Lisa J HerrintonKenneth G Saag
Nov 5, 2016·Journal of Veterinary Emergency and Critical Care·Samantha K Hart, Lori Waddell
Oct 18, 2018·Journal of Clinical Medicine·Sarah SkeochNazia Chaudhuri
May 30, 2020·The Pharmacogenomics Journal·Takuya ImatohMasayuki Hanaoka
Apr 14, 2016·Respirology : Official Journal of the Asian Pacific Society of Respirology·Yoon-Kyoung LeeJoongbum Cho

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