Drug reaction with eosinophilia and systemic symptoms related to antiretroviral treatment in human immunodeficiency virus patients

Indian Journal of Sexually Transmitted Diseases and AIDS
David BrandarizVanesa Anton-Vazquez

Abstract

The drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome is a life-threatening condition caused by different medications. The objective of this study was to analyze DRESS cases related to antiretroviral therapy in human immunodeficiency virus (HIV) patients. Systematic review of DRESS suspected cases in HIV patients associated to antiretrovirals published between January 1998 and April 2017. The registry of the severe cutaneous adverse reactions score was used to classify each report as a "definitive," "probable," "possible," or "no" DRESS case. Clinical characteristics, management, and outcomes were evaluated. Thirty-five case reports were analyzed involving 5 antiretrovirals: Abacavir in 10 (28.6%) cases, efavirenz in 6 (17.1%), nevirapine in 12 (34.3%), raltegravir in 6 (17.1%), and tenofovir in 1 (2.9%). Mean age of the patients was 40 ± 13 years, 65% of which were male. A total of 57.1% reports were classified as having a "definitive-probable" DRESS case. Management was based on withdrawal of the causal antiretroviral and corticosteroids in 68.6% of the cases. None of the patients died. Treatment with nevirapine or raltegravir, the longer onset of symptoms and the presence of lymphadenopathy, eosinophilia...Continue Reading

Citations

Feb 27, 2019·American Journal of Clinical Dermatology·Khatiya ChelidzeEsther Ellen Freeman
Jan 18, 2019·American Journal of Clinical Dermatology·Sylvia Aide Martínez-CabrialesNeil H Shear
May 2, 2020·Expert Opinion on Drug Safety·Sofía ScévolaDaniel Podzamczer
Dec 14, 2018·Journal of Clinical Medicine·Philipp GaucklerAndreas Kronbichler

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BETA
biopsy
PCR

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RegiSCAR
SPSS

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