PMID: 6403961Jan 1, 1983Paper

Drug reinstatement of heroin-reinforced responding in the rat

Psychopharmacology
H de Wit, J Stewart

Abstract

Non-contingent, 'priming' IV drug injections led to reinstatement of heroin-reinforced responding after a period of extinction. Rats implanted with IV catheters were trained to self-administer heroin (100 micrograms/kg/infusion diacetylmorphine HCl) and were given test sessions consisting of a period of self-administration followed by extinction conditions. 'Priming' infusions of heroin and other drugs were presented during extinction and lever pressing following the injection was observed. Priming injections of 50, 100 and 200 micrograms/kg heroin effectively restored responding after a period of extinction. Morphine and, to a lesser extent, amphetamine and apomorphine also reinstated heroin-reinforced responding whereas cocaine and clonidine did not. These results may help our understanding of 'relapse of drug-taking' behavior.

References

Oct 1, 1978·Pharmacology, Biochemistry, and Behavior·L L HernandezJ B Appel
Jan 1, 1978·The American Journal of Drug and Alcohol Abuse·M B Sobell
Jan 1, 1981·Psychopharmacology·H de Wit, J Stewart

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Citations

Jan 1, 1989·Psychopharmacology·J H JaffeM A Sherer
Jan 1, 1993·Psychopharmacology·A MarkouG F Koob
Sep 1, 1995·Psychopharmacology·S D ComerM E Carroll
Apr 1, 1996·Psychopharmacology·A EttenbergT D Geist
Jan 1, 1992·Psychopharmacology·W M ChornockS Leischow
Sep 1, 1996·Psychopharmacology·C ChiamuleraM Tessari
Dec 17, 2008·Neurotoxicity Research·Roy A Wise
Jun 15, 2007·Psychopharmacology·Ayelet CooperAbraham Zangen
Jun 26, 2008·Psychopharmacology·Van A Redila, Charles Chavkin
Jan 18, 2007·Behavior Genetics·Morgane Thomsen, S Barak Caine
Jun 8, 2007·Cellular and Molecular Neurobiology·Gregg R WardAllyn C Howlett
Jun 1, 1984·Pharmacology, Biochemistry, and Behavior·P Vezina, J Stewart
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·S I Lawley, K M Kantak
Jul 1, 1990·Pharmacology, Biochemistry, and Behavior·A Ettenberg
May 1, 1994·Pharmacology, Biochemistry, and Behavior·C M WorleyS Schenk
May 1, 1992·Trends in Pharmacological Sciences·I Stolerman
May 1, 1992·Trends in Pharmacological Sciences·G Di Chiara, R A North
Jan 1, 1983·Progress in Neuro-psychopharmacology & Biological Psychiatry·J Stewart
Nov 10, 2013·European Journal of Pharmacology·Aashish S MoraniBronwyn M Kivell
Jun 7, 2005·Pharmacology, Biochemistry, and Behavior·Eliot L Gardner
Dec 31, 2002·Chemistry and Physics of Lipids·Eliot L Gardner
May 21, 1998·European Journal of Pharmacology·S D ComerM W Fischman
Feb 7, 2002·Pharmacology, Biochemistry, and Behavior·Ronald E See
Oct 9, 1999·Pharmacology, Biochemistry, and Behavior·R D SpealmanT V Khroyan
Feb 23, 2000·Pharmacology, Biochemistry, and Behavior·K N GracyG F Koob
Nov 3, 2001·Brain Research. Brain Research Reviews·B J EverittT W Robbins

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