Drug-related deaths in a department of internal medicine

Archives of Internal Medicine
J EbbesenL Sandvik

Abstract

Drug therapy is associated with adverse effects, and fatal adverse drug events (ADEs) have become major hospital problems. Our study assesses the incidence of fatal ADEs in a major medical department and identifies possible patient characteristics signifying fatal ADE risk. During a 2-year period, a multidisciplinary study group examined all 732 patients who died--5.2% of the 13992 patients admitted to the Department of Internal Medicine, Central Hospital of Akershus, Nordbyhagen, Norway. Decisions about the presence or absence of fatal ADEs were based on aggregated clinical records, autopsy results, and findings from premortem and postmortem drug analyses. In 18.2% of the patients (133/732) (95% confidence interval, 15.4%-21.0%), deaths were classified as being directly (64 [48.1%] of 133) or indirectly (69 [51.9%] of 133) associated with 1 or more drugs (this equals 9.5 deaths per 1000 hospitalized patients). Those with fatal ADEs (cases) were older, had more diseases, and used more drugs than those without fatal ADEs (noncases). In 75 of the 133 patients with fatal ADEs, autopsy findings and/or drug analysis data were decisive for recognizing the ADEs; in 62 of the remaining 595 patients, similar data proved necessary to exc...Continue Reading

Citations

Dec 19, 2013·International Journal of Clinical Pharmacy·Lene Juel KjeldsenTrine Rune Høgh Nielsen
Jul 16, 2014·Forensic Science International : Synergy·Michelangelo Bruno CasaliUmberto Genovese
Jun 26, 2007·International Journal of Health Care Quality Assurance·Ingeborg K BjörkmanCecilia B Bernsten
Jun 7, 2003·Quality & Safety in Health Care·J D RozichR K Resar
Dec 24, 2003·BMC Nephrology·Harold J ManleyRichard S Muther
Dec 22, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Vibeke JuliebøTorgeir B Wyller
Jul 19, 2012·Zeitschrift für Gerontologie und Geriatrie·M Gosch, K Pils
Mar 13, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·G Cecilie AlfsenHelge Svaar
Oct 23, 2010·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Mark Fagan, Stian Bøe Skotheim
Jan 25, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Mari BaardsethLars Slørdal
Jun 14, 2013·Tidsskrift for den Norske lægeforening : tidsskrift for praktisk medicin, ny række·Erik Øglænd Bjørnestad, Anette Hylen Ranhoff
Oct 3, 2009·Der Internist·M VölkelJ C Frölich
Apr 29, 2011·International Journal of Clinical Pharmacy·Kazeem B Yusuff, Fola Tayo
Oct 27, 2004·Nature Biotechnology·Christopher P RusconiBruce A Sullenger
Apr 29, 2009·Journal of Medical Systems·Steven D CullerKimberly Rask
Apr 13, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Carmen M FaulknerJohn C Williamson
Feb 22, 2016·European Journal of Clinical Pharmacology·Alfredo José Pardo CabelloEmilio Puche Cañas
Aug 27, 2013·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Harold J Manley, Amy Barton-Pai
Jun 27, 2015·Basic & Clinical Pharmacology & Toxicology·Outi Lapatto-ReiniluotoPertti J Neuvonen
Apr 17, 2012·Clinics in Geriatric Medicine·Bo Hovstadius, Göran Petersson
Jan 24, 2012·Revista de calidad asistencial : organo de la Sociedad Española de Calidad Asistencial·C González SteinbauerV Zanón Viguer
Apr 2, 2011·Journal of Pain and Symptom Management·Vanessa MirandaRachel P Riechelmann
Nov 26, 2010·Nanomedicine : Nanotechnology, Biology, and Medicine·Ioannis S Vizirianakis
Jun 30, 2009·Forensic Science International : Synergy·Burkhard MadeaJohanna Preuss
Jun 16, 2009·Forensic Science International : Synergy·Burkhard Madea, Johanna Preuss
Jul 31, 2007·Ageing Research Reviews·M Shawkat Razzaque
Sep 27, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Harold J ManleyWendy L St Peter
Oct 16, 2004·Journal of Evaluation in Clinical Practice·Hugh McGavock
Dec 9, 2004·Pharmacotherapy·Ann K WittkowskyOle Hauch
Jan 9, 2009·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·R MirakianUNKNOWN BSACI
Sep 15, 2006·Journal of the American Geriatrics Society·Masafumi KuzuyaAkihisa Iguchi
Jan 31, 2009·Pharmacoepidemiology and Drug Safety·Ding-Cheng Derrick ChanShwu-Chong Wu
May 12, 2006·Journal of the American Geriatrics Society·Masafumi KuzuyaAkihisa Iguchi
Oct 14, 2006·Journal of the American Geriatrics Society·Michael A SteinmanPeter J Kaboli
Sep 3, 2010·Journal of Evaluation in Clinical Practice·Gerry ArmitageJohn Wright
Jun 9, 2012·Pharmacoepidemiology and Drug Safety·Antonio Pintor-MármolMaria José Faus
Dec 10, 2009·Pharmacoepidemiology and Drug Safety·Anna K JönssonStaffan Hägg
Sep 3, 2005·European Journal of Internal Medicine·H Wyles, H U Rehman

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Eric WeinhandlWendy St Peter
Advances in Chronic Kidney Disease
Katie E CardoneHarold Manley
American Journal of Health-system Pharmacy : AJHP : Official Journal of the American Society of Health-System Pharmacists
Paul C WalkerJohn S Clark
American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
Harold ManleyRichard S Muther
© 2021 Meta ULC. All rights reserved