Drug-related Problems in Home-dwelling Older Adults: A Systematic Review

Clinical Therapeutics
Ana I PlácidoFátima Roque

Abstract

The complex combination of medicines associated with age-related physiological alterations leads older adults to experience drug-related problems (DRPs). The goal of this study was to review the frequency and type of DRPs and DRP risk factors in home-dwelling older adults. A MEDLINE PubMed and EMBASE scientific databases search was performed. Articles published from January 2000 through December 2018 reporting DRPs in home-dwelling older adults were included. From 668 articles screened, 13 met the inclusion criteria and were included in this study. Overall, the studies included 8935 home-dwelling patients. The mean number of DRPs per patient observed was 4.16 (1.37-10). The main causes of DRPs were "drug selection" (51.41%), "dose selection" (11.62%), and "patient related" (10.70%) problems. The drug classes more frequently associated with DRPs were "cardiovascular system," "alimentary tract and metabolism," and "nervous system," and they represented 32.1%, 29.4%, and 16.5% of all drug selection problems, respectively. Respiratory system medicines accounted for 6.65% of all DRPs, of which "patient related" problems accounted for 97.28%. Despite the heterogeneity of methodology of the included studies and the heterogeneity of to...Continue Reading

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Citations

Sep 10, 2020·International Journal of Environmental Research and Public Health·Ana Isabel PlácidoFátima Roque
Mar 22, 2021·European Geriatric Medicine·Marie-Laure LarocheLouis Merle
Jul 25, 2021·International Journal of Environmental Research and Public Health·Ana Rita PaivaFátima Roque
Sep 8, 2021·Frontiers in Pharmacology·Xiao-Feng NiLing-Li Zhang

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