Drug-related talaromycosis: A case report.

International Journal of Immunopathology and Pharmacology
Yongsheng LuJing Yu

Abstract

Talaromycosis is a rare deep fungal infection caused by Talaromyces marneffei. Currently, methamphetamine has become the second-largest drug abuse category in the world after cannabis and has become a serious public health problem. Methamphetamine can inhibit human immune system and increase the probability of pathogenic microorganism infection. On 8 October 2016, a 20-year-old man with a fever history of 2 months was admitted to our hospital. He had bloody stools and abdominal pain during hospitalization. There was no significant abnormality in physical examination. Because of the misdiagnosis, he underwent improper treatment. Periodic acid-Schiff stain (PAS) staining showed that the mucosa of distal ileum, ascending colon, transverse colon, and sigmoid colon were infiltrated by a large number of tissue cells, which contained a large number of blue purple particles. In addition, a large number of histiocytes and multinucleated giant cells can be seen in the lamina propria of ileum mucosa, and fungal spores can be seen in histiocytes. Finally, he was diagnosed as talaromycosis and took itraconazole 0.2 g twice a day. After 5 days, the temperature dropped to normal and the inflammation disappeared, and he continued to take itrac...Continue Reading

References

Jun 4, 1998·Journal of Neuroimmunology·T K HughesE M Smith
Sep 18, 2012·Mycopathologia·Yongxuan HuLiyan Xi
Oct 1, 2014·PloS One·Xiaowen HuangEleftherios Mylonakis
Mar 18, 2017·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Monica D PrakashVasso Apostolopoulos
Aug 5, 2017·The Lancet Infectious Diseases·Andrew H LimperThomas S Harrison
Aug 24, 2017·Current Infectious Disease Reports·Daniel B ChastainCarlos Franco-Paredes

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