May 1, 1979

Drug related vasculitis. Clinicopathologic correlations in 30 patients

Human Pathology
F G MullickJ J Fenoglio


Drug related vasculitis has variously been described as necrotizing hypersensitivity or allergic angiitis or microscopic panarteritis nodosa. We reviewed tissue sections from 30 patients with validated drug hypersensitivity and vasculitis in order to precisely define this entity. No evidence of necrotizing vascular lesions or of fibrinoid associated with necrosis was found. The vascular lesions in all 30 patients involved small arteries, arterioles, capillaries, and venules. The inflammatory infiltrate consisted primarily of mononuclear cells and prominent numbers of eosinophils and was present in all three layers of the involved vessel walls. Clinically the patients developed either localized or systemic vasculitis, which could not be predicted on the basis of the associated drug. The findings of a skin rash, fever, or eosinophilia and the development of symptoms consistent with a hypersensitivity reaction while medication was being taken were all suggestive of the diagnosis of drug related vasculitis.

  • References
  • Citations45


  • We're still populating references for this paper, please check back later.

Mentioned in this Paper

Arterial System
Mononuclear Cells
Churg-Strauss Syndrome
Blood Vessel
Structure of Parietal Pericardium
Vascular Lesions

About this Paper

Related Feeds

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Related Papers

Scandinavian Journal of Respiratory Diseases
F VeevaeteH Roels
Nihon rinsho. Japanese journal of clinical medicine
R Amitani, F Kuze
© 2020 Meta ULC. All rights reserved