PMID: 8592686Nov 1, 1995Paper

Drug release from hydrocolloid embeddings with high or low susceptibility to hydrodynamic stress

Pharmaceutical Research
W D Lindner, B C Lippold

Abstract

The subject of the study was the influence of hydrodynamic stress on the drug release from direct compressed hydrocolloid embeddings. Additionally a correlation between the release kinetics and different polymer characterising parameters was attempted. The drug release was fitted to an expanded Korsmeyer equation to describe the release kinetics. The influence of the stirring Dissolution Time (MDT) was expressed as quotient of the MDT's at the stirring rate of 200 and 100 min-1. If the drug release followed the square root of time kinetics, nearly no effect of the agitation speed on the release rate was observed. To achieve this diffusion controlled drug release the developing gel layer had to be hydrated very well and resistant against erosion (viscosity of at least 4000 mPa.s of the 2% polymer solution and a small expansion of the swelling gel especially at the beginning of the release). The erosion controlled zero order release was generally much affected by the hydrodynamic stress except for some hydrocolloids with incomplete swelling. Thus, it was possible to define a new release mechanism, the polymer particle erosion. The drug release was controlled by the attrition of partially swollen polymer particles and not by the p...Continue Reading

Citations

Apr 9, 1998·Pharmaceutical Development and Technology·M M TalukdarR Kinget
Apr 29, 2016·Journal of Microencapsulation·Howida Kamal Ibrahim, Salwa Salah
Jun 14, 2003·The Journal of Pharmacy and Pharmacology·Annette ScholzJennifer B Dressman
Jun 17, 2008·Biotechnology and Bioengineering·D Ece GamsizRebecca L Carrier
Oct 1, 2008·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Gladius Lewis
Jun 24, 2011·Drug Development and Industrial Pharmacy·Gladious Naguib El-HadidyMohamed Farid El-Milligi
Dec 28, 2011·Journal of Materials Science. Materials in Medicine·Javier AragónDavide Viterbo
Jan 1, 2010·Annual Review of Chemical and Biomolecular Engineering·William B LiechtyNicholas A Peppas
Mar 20, 2013·Pharmaceutical Development and Technology·Waseem KaialyAli Nokhodchi
Oct 19, 2016·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Wayne Nishio AyreStephen P Denyer
Sep 7, 2017·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Joshua SlaneMatthew Squire
Jun 1, 1999·Drug Development and Industrial Pharmacy·B AbrahamssonJ Sjögren
Jun 24, 2015·Drug Delivery and Translational Research·Xu Wen NgSubbu S Venkatraman
Mar 22, 2013·AAPS PharmSciTech·Ragwa M FaridAbd El Azeem R Ebian
Dec 29, 2020·Pharmaceutical Development and Technology·Mohamed Ahmed Naseef SolimanSamia Abd El-Kader Nour
Sep 10, 1999·Journal of Pharmaceutical Sciences·V Pillay, R Fassihi

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