Drug release from ion-exchange microspheres: mathematical modeling and experimental verification

Biomaterials
Mohammad J Abdekhodaie, Xiao Yu Wu

Abstract

This paper presents for the first time a mathematical model for a mechanism of controlled drug release involving both ion exchange and transient counter diffusion of a drug and counterions. Numerical analysis was conducted to study the effect of different factors on drug release kinetics including environmental condition, material properties, and design parameters. The concentration profiles of counterions and drug species, the moving front of ion exchange, and three distinct regions inside a microsphere, namely unextracted region, ion-exchange region and drug diffusion region, were revealed by model prediction. The numerical results indicated that the rate of drug release increased with an increase in the initial drug concentration in the microspheres, the salt concentration in the external solution, or the valence of the counterions, whereas it decreased with increasing Langmuir isotherm constant. The mathematical and experimental procedures for determination of the equilibrium constant and the usefulness of the model were demonstrated using verapamil hydrochloride and sulfopropyl dextran microsphere system as an example. This work has provided a very useful mathematical tool for predicting kinetics and equilibrium of drug re...Continue Reading

References

Nov 11, 1999·Biomaterials·T TarvainenK Järvinen
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Jun 8, 2002·International Journal of Pharmaceutics·Vincent BoudyJean Claude Chaumeil
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Mar 7, 2006·Biomaterials·Mohammad J Abdekhodaie, Xiao Yu Wu

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Citations

Aug 10, 2011·Journal of Colloid and Interface Science·Ling Shan ZhengLi Juan Zhang
Dec 5, 2009·Journal of Controlled Release : Official Journal of the Controlled Release Society·Rachael W SirianniW Mark Saltzman
Sep 30, 2008·International Journal of Pharmaceutics·J Siepmann, F Siepmann
Apr 15, 2008·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yongqiang LiXiao Yu Wu
May 20, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Yongqiang LiXiao Yu Wu
Nov 5, 2016·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yousheng ZhouXiao Yu Wu

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