Abstract
Poly(lactide-co-glycolic acid) (PLGA) and poly(L-lactide) (PLLA) films are widely studied for various biomedical applications. Because of their use for drug delivery, achieving controlled release from these biodegradable films has become an area of intense research. The objective of this study is therefore to investigate how PLGA and PLLA films fabricated through an irradiated-multi-layer approach can be a viable technique to achieve controlled drug delivery. In this study, lidocaine base (lido-base) and lidocaine salt (lido-salt) were used as model hydrophobic and hydrophilic drugs, respectively. Results show that multi-layer PLGA underwent pseudo surface degradation, while multi-layer PLLA degraded to a lesser extent over the same study period. Triphasic release was observed for lido-base, whereas lido-salt was released through a biphasic profile, from both polymer systems. The two dominating release phases for both drugs were diffusion and zero-order release, where the latter is characterized by the onset of mass loss. It was shown that PLGA had a shorter diffusion phase and a longer zero-order phase, while the contrary was true for PLLA. This difference was due to the faster degradation for PLGA. In conclusion, the hydrophi...Continue Reading
References
Jan 1, 1996·Biomaterials·K A AthanasiouC M Agrawal
Jul 25, 2000·Circulation·H TamaiH Uehata
Feb 13, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·K S SoppimathW E Rudzinski
Feb 24, 2001·Journal of Biomaterials Science. Polymer Edition·M Gümüşderelioglu, G Deniz
Jun 25, 2002·The Journal of Pharmacy and Pharmacology·M Jesús DortaJosé B Fariña
Oct 18, 2002·Advanced Drug Delivery Reviews·A Göpferich, J Tessmar
Jan 29, 2003·International Journal of Pharmaceutics·P PeruginiF Pavanetto
Dec 1, 1963·Journal of Pharmaceutical Sciences·T HIGUCHI
Jun 24, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Shajahan Abdul, S S Poddar
Sep 15, 2004·International Journal of Pharmaceutics·John K JacksonHelen M Burt
Oct 16, 2004·Biomaterials·J S C LooF Y C Boey
Jan 1, 2005·Biomaterials·Say Chye Joachim LooYin Chiang Freddy Boey
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·C Raman, A J McHugh
Jan 18, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Alexis FrankSubbu S Venkatraman
Sep 16, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Mei-Chin ChenHsing-Wen Sung
Jan 3, 2006·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Sheng-Fu HuangChiao-Hsi Chiang
Feb 10, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Ulrich WestedtThomas Kissel
Aug 2, 2006·Biomaterials·Xintong WangLay Poh Tan
Mar 28, 2007·Journal of Materials Science. Materials in Medicine·Katrin SternbergKlaus-Peter Schmitz
Aug 28, 2007·Journal of Pharmaceutical Sciences·Farahidah Mohamed, Christopher F van der Walle
Oct 10, 2007·Journal of Pharmaceutical Sciences·Jingwei XieChi-Hwa Wang
Dec 7, 2007·International Journal of Pharmaceutics·D KloseJ Siepmann
Feb 16, 2008·Journal of Drug Targeting·Suphiya Parveen, Sanjeeb K Sahoo
Apr 26, 2008·Journal of Biomedical Materials Research. Part a·Dermot J LeonardFraser J Buchanan
Jun 3, 2008·International Journal of Pharmaceutics·Say Chye Joachim LooFreddy Boey
Sep 6, 2008·International Journal of Pharmaceutics·R A ThakurB B Michniak
Citations
May 22, 2013·Biotechnology Letters·Atul Nayak, Diganta Bhusan Das
Feb 22, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lilian GonzalezJin-Hong Chang
Jan 11, 2014·International Journal of Molecular Sciences·Wei QianLu Wang
May 25, 2011·Journal of Pharmaceutical Sciences·Terry W J SteeleSubbu S Venkatraman
Feb 2, 2012·Acta Biomaterialia·Terry W J SteeleSubbu S Venkatraman
Jul 27, 2011·Journal of Controlled Release : Official Journal of the Controlled Release Society·Yanhong WenHanne Mørck Nielsen
Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
Feb 9, 2011·Acta Biomaterialia·Terry W J SteeleSubbu S Venkatraman
Jul 15, 2015·Journal of Controlled Release : Official Journal of the Controlled Release Society·Sílvia Castro CoelhoManuel A N Coelho
Oct 27, 2012·Acta Biomaterialia·D G YuY Z Liao
Aug 12, 2015·Advanced Biomedical Research·Mehrdad MohammadpourElham Delrish
Apr 15, 2015·Acta Biomaterialia·Piergiorgio GentilePaul V Hatton
Sep 18, 2012·International Journal of Pharmaceutics·Yong-Nan JiangDeng-Guang Yu
May 26, 2017·Journal of Pharmaceutical Sciences·Lucila NavarroIgnacio Rintoul
Jun 29, 2013·Cancer Biotherapy & Radiopharmaceuticals·Jun ZhaoLongbao Xu
Sep 29, 2012·Small·Mustafa Hussain KathawalaSay Chye Joachim Loo
Sep 24, 2015·Biomedical Materials·Mi Hee LeeJong-Chul Park
Oct 11, 2019·Royal Society Open Science·Naoki OsadaToshihiro Kasuga
May 19, 2011·Macromolecular Rapid Communications·Wei Li LeeSay Chye Joachim Loo
May 4, 2018·Frontiers in Pharmacology·Zhenyang MaoBing Yue
Apr 27, 2019·Frontiers in Chemistry·Tina MaverUroš Maver
Jan 16, 2019·International Journal of Molecular Sciences·Minghan ChiHockin H K Xu
May 6, 2017·Drug Delivery·Li GaoLan Luo
Jun 29, 2012·Journal of Drug Targeting·Wei Li Lee, Say Chye Joachim Loo
May 1, 2021·Polymers·Anita Ioana VisanGabriel Socol
Jul 17, 2021·Scientific Reports·Crystal E RapierAbraham P Lee
May 8, 2019·ACS Applied Bio Materials·Alexis M ZiembaRyan J Gilbert