Drug release from irradiated PLGA and PLLA multi-layered films

Journal of Pharmaceutical Sciences
Say Chye Joachim LooSiew Ling Ivy Lin

Abstract

Poly(lactide-co-glycolic acid) (PLGA) and poly(L-lactide) (PLLA) films are widely studied for various biomedical applications. Because of their use for drug delivery, achieving controlled release from these biodegradable films has become an area of intense research. The objective of this study is therefore to investigate how PLGA and PLLA films fabricated through an irradiated-multi-layer approach can be a viable technique to achieve controlled drug delivery. In this study, lidocaine base (lido-base) and lidocaine salt (lido-salt) were used as model hydrophobic and hydrophilic drugs, respectively. Results show that multi-layer PLGA underwent pseudo surface degradation, while multi-layer PLLA degraded to a lesser extent over the same study period. Triphasic release was observed for lido-base, whereas lido-salt was released through a biphasic profile, from both polymer systems. The two dominating release phases for both drugs were diffusion and zero-order release, where the latter is characterized by the onset of mass loss. It was shown that PLGA had a shorter diffusion phase and a longer zero-order phase, while the contrary was true for PLLA. This difference was due to the faster degradation for PLGA. In conclusion, the hydrophi...Continue Reading

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Citations

May 22, 2013·Biotechnology Letters·Atul Nayak, Diganta Bhusan Das
Feb 22, 2013·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Lilian GonzalezJin-Hong Chang
Jan 11, 2014·International Journal of Molecular Sciences·Wei QianLu Wang
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Jun 7, 2011·International Journal of Pharmaceutics·Susanne FredenbergAnders Axelsson
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Sep 18, 2012·International Journal of Pharmaceutics·Yong-Nan JiangDeng-Guang Yu
May 26, 2017·Journal of Pharmaceutical Sciences·Lucila NavarroIgnacio Rintoul
Oct 11, 2019·Royal Society Open Science·Naoki OsadaToshihiro Kasuga
May 19, 2011·Macromolecular Rapid Communications·Wei Li LeeSay Chye Joachim Loo
Jan 16, 2019·International Journal of Molecular Sciences·Minghan ChiHockin H K Xu
Jun 29, 2012·Journal of Drug Targeting·Wei Li Lee, Say Chye Joachim Loo

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