Drug Repositioning for Schizophrenia and Depression/Anxiety Disorders: A Machine Learning Approach Leveraging Expression Data

IEEE Journal of Biomedical and Health Informatics
Kai Zhao, Hon-Cheong So

Abstract

Development of new medications is a lengthy and costly process, and drug repositioning might help to shorten the development cycle. We present a machine learning (ML) workflow to drug discovery or repositioning by predicting indication for a particular disease based on drug expression profiles, with a focus on applications in psychiatry. Drugs that are not originally indicated for the disease but with high predicted probabilities serve as candidates for repurposing. This approach is widely applicable to any chemicals or drugs with expression profiles measured, even if drug targets are unknown. It is also highly flexible as virtually any supervised learning algorithms can be used. We employed the ML approach to identify repositioning opportunities for schizophrenia as well as depression and anxiety disorders. We applied various state-of-the-art ML approaches, including deep neural networks (DNNs), support vector machines (SVMs), elastic net regression, random forest, and gradient boosted trees. The predictive performance of the five approaches in cross validation did not differ substantially, with SVM slightly outperforming the others. However, other methods also reveal literature-supported repositioning candidates of different ...Continue Reading

Citations

Aug 11, 2019·Psychiatry and Clinical Neurosciences·Abhishek AppajiNaren P Rao
Feb 23, 2020·International Clinical Psychopharmacology·Chiara FabbriAlessandro Serretti
Nov 16, 2019·BMC Bioinformatics·Mahroo MoridiFatemeh Zare-Mirakabad
Jan 7, 2020·CPT: Pharmacometrics & Systems Pharmacology·Alan TaleviDaniela J Conrado
Jul 17, 2020·Computational and Structural Biotechnology Journal·Alexandria Lau, Hon-Cheong So
Oct 16, 2020·Chemical Biology & Drug Design·Firoozeh PiroozmandHedieh Sajedi
May 19, 2021·Progress in Biophysics and Molecular Biology·Harshita Singh, Navneeta Bharadvaja
Jun 7, 2021·Medical & Biological Engineering & Computing·Manjunath Tadalagi, Amit M Joshi
Oct 15, 2020·Revista brasileira de psiquiatria : orgão oficial da Associação Brasileira de Psiquiatria, Asociación Psiquiátrica de la América Latina·Mary S MuffordShareefa Dalvie
Aug 28, 2021·Life·Hosna Mohammad SadeghiMohammad Abdollahi
Jan 8, 2022·Journal of Biomolecular Structure & Dynamics·Santanu SasidharanPrakash Saudagar

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