Drug Repurposing: A Review of Old and New Antibiotics for the Treatment of Malaria: Identifying Antibiotics with a Fast Onset of Antiplasmodial Action.

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Lais Pessanha de CarvalhoJana Held

Abstract

Malaria is one of the most life-threatening infectious diseases and constitutes a major health problem, especially in Africa. Although artemisinin combination therapies remain efficacious to treat malaria, the emergence of resistant parasites emphasizes the urgent need of new alternative chemotherapies. One strategy is the repurposing of existing drugs. Herein, we reviewed the antimalarial effects of marketed antibiotics, and described in detail the fast-acting antibiotics that showed activity in nanomolar concentrations. Antibiotics have been used for prophylaxis and treatment of malaria for many years and are of particular interest because they might exert a different mode of action than current antimalarials, and can be used simultaneously to treat concomitant bacterial infections.

References

Jul 1, 1990·International Journal for Parasitology·A F Cowman, S J Foote
Dec 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·D J BzikJ Inselburg
Dec 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D S PetersonT E Wellems
Mar 1, 1989·The American Journal of Tropical Medicine and Hygiene·C NaquiraM Aziz
Feb 1, 1982·Antimicrobial Agents and Chemotherapy·T MurakawaM Nishida
Jan 1, 1997·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·P Huovinen
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·R F WallerG I McFadden
May 31, 2001·Microbiology and Molecular Biology Reviews : MMBR·I Chopra, M Roberts
Aug 16, 2001·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Tony Triglia, Alan F. Cowman
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Bertrand Lell, Peter G Kremsner
Aug 17, 2002·Antimicrobial Agents and Chemotherapy·Jochen WiesnerHassan Jomaa
Sep 3, 2002·International Journal for Parasitology·Frank Seeber
Oct 5, 2002·Journal of Clinical Pharmacology·Cynthia A GuzzoKenneth C Lasseter
Dec 21, 2002·Lancet·Michel A MissinouPeter G Kremsner
Jan 25, 2003·Antimicrobial Agents and Chemotherapy·Bertrand LellPeter Gottfried Kremsner
Feb 21, 2004·The Journal of Infectious Diseases·Steffen BorrmannPeter G Kremsner
Apr 15, 2004·Nature Reviews. Microbiology·Stuart A RalphGeoffrey I McFadden
Jun 10, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Joseph KamgnoMichel Boussinesq
Jul 1, 1985·Parasitology Today·W C Campbell
Aug 24, 2004·Brazilian Dental Journal·Elio Hitoshi ShinoharaAndré Takahashi
Oct 16, 2004·International Journal of Dermatology·Andrés R SánchezPhillip J Sheridan
Aug 30, 2005·Antimicrobial Agents and Chemotherapy·Steffen BorrmannPeter G Kremsner
Oct 20, 2005·The Journal of Infectious Diseases·Mahamadou A TheraChristopher V Plowe
May 26, 2006·Antimicrobial Agents and Chemotherapy·Matthew W OlsonPatricia A Bradford
Jul 28, 2006·Antimicrobial Agents and Chemotherapy·Steffen BorrmannPeter G Kremsner
Aug 31, 2006·Antimicrobial Agents and Chemotherapy·Erica L DahlPhilip J Rosenthal
Apr 11, 2007·The Journal of Antibiotics·Stjepan Mutak
Aug 19, 2007·Antimicrobial Agents and Chemotherapy·Erica L Dahl, Philip J Rosenthal
Jul 15, 2009·Antimicrobial Agents and Chemotherapy·P StarzengruberH Noedl
Oct 21, 2009·Antimicrobial Agents and Chemotherapy·Jana HeldBenjamin Mordmüller
Feb 4, 2010·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Liting Lim, Geoffrey Ian McFadden
Mar 17, 2010·International Journal of Antimicrobial Agents·Jana HeldBenjamin Mordmüller
Mar 25, 2010·Current Molecular Medicine·G Pradel, M Schlitzer

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry
Diana FontinhaMiguel Prudêncio
South African Medical Journal = Suid-Afrikaanse Tydskrif Vir Geneeskunde
J RamanI S Ukpe
© 2021 Meta ULC. All rights reserved