Drug repurposing for the treatment of staphylococcal infections

Current Pharmaceutical Design
Shankar ThangamaniMohamed N Seleem

Abstract

The development and approval of new antimicrobials capable of being used to treat infections caused by multidrug-resistant pathogens has not kept pace with the rapid emergence of bacterial resistance. Without a doubt, there is a critical unmet need for the identification of novel strategies to develop antimicrobials to deal with this new scourge. One strategy, which warrants special attention as a unique method for identifying new antimicrobials, is drug repurposing. Several approved drugs have been successfully repurposed for different ailments giving hope that this strategy can also be utilized to uncover new antibacterials. To aid in this process, the present review presents non-antimicrobial approved drugs and clinical molecules, which have been shown to possess antimicrobial activity against Staphylococcus aureus and their potential clinical applications. Additionally, approved drugs with novel applications such as interference in staphylococcal pathogenesis and host immunomodulators are also explained. The current review also discusses the challenges associated with repurposing already approved non-antimicrobial drugs as antibacterials and potential uses of these drugs that can be further explored in order to develop nove...Continue Reading

Citations

Feb 21, 2016·International Journal of Antimicrobial Agents·Shankar ThangamaniMohamed N Seleem
Jun 27, 2015·Scientific Reports·Shankar ThangamaniMohamed N Seleem
Aug 19, 2015·Frontiers in Microbiology·Shankar ThangamaniMohamed N Seleem
Jul 30, 2015·PloS One·Shankar ThangamaniMohamed N Seleem
Oct 23, 2016·Biochimica Et Biophysica Acta. General Subjects·Shankar ThangamaniMohamed N Seleem
Nov 11, 2015·Scientific Reports·Shankar ThangamaniMohamed N Seleem
Feb 22, 2017·Journal of Pediatric Health Care : Official Publication of National Association of Pediatric Nurse Associates & Practitioners·Leah Molloy
Jun 29, 2018·PloS One·Ahmed AbdelKhalekMohamed N Seleem
Jan 16, 2019·Antimicrobial Agents and Chemotherapy·Andrew C MarshallJohn B Bruning
Oct 2, 2019·Antimicrobial Agents and Chemotherapy·Marwa AlhashimiMohamed N Seleem
May 13, 2020·Antimicrobial Agents and Chemotherapy·Young Jin SeongMohamed N Seleem
Mar 7, 2020·The Journal of Antibiotics·Ahmed AbdelKhalekMohamed N Seleem
Jun 20, 2020·Brazilian Journal of Microbiology : [publication of the Brazilian Society for Microbiology]·Ling-Ning MengMing-Jie Xiang
Feb 6, 2017·Frontiers in Cellular and Infection Microbiology·Shankar ThangamaniMohamed N Seleem
May 31, 2018·Scientific Reports·Ahmed AbdelKhalekMohamed N Seleem
Jun 4, 2021·Frontiers in Cellular and Infection Microbiology·Natalie K BoydChristopher R Frei
Sep 25, 2021·Journal of Global Antimicrobial Resistance·Natalie K BoydChristopher R Frei

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