Drug residues in serum of dogs receiving anticancer chemotherapy

Journal of Veterinary Internal Medicine
A KnoblochD Simon

Abstract

The presence of drug residues in blood samples can represent an occupational hazard. However, studies on cytotoxic drug residues in serum of dogs are lacking in veterinary oncology. To evaluate possible occupational hazards associated with handling of blood samples from dogs receiving oncolytic drugs 7 days after treatment. Twenty-seven client-owned dogs treated for lymphoma or mast cell tumors with vincristine, vinblastine, cyclophosphamide, or doxorubicin. Prospective, observational study. Serum samples were either taken 7 days after administration of vincristine, cyclophosphamide, doxorubicin (lymphoma), and vinblastine (mast cell tumor), or 1-2 days after the last concurrent oral administration of cyclophosphamide (mast cell tumor). Additionally, serum was collected within 5 minutes of treatment. Measurement of drug residues in serum was performed by liquid chromatography tandem mass spectrometry (LC/MS/MS). In 33 samples collected within 5 minute of treatment, the median serum concentrations were vincristine: 37 microg/L (range: 11-87 microg/L), vinblastine: 13 microg/L (range: 13-35 microg/L), cyclophosphamide: 2,484 microg/L (range: 1,209-2,778 microg/L), doxorubicin: 404 microg/L (range: 234-528 microg/L). In 81 serum s...Continue Reading

References

Feb 1, 1992·International Journal of Cancer. Journal International Du Cancer·E M Goloni-BertolloM Varella-Garcia
Jan 1, 1991·American Journal of Industrial Medicine·S Milković-Kraus, D Horvat
Mar 1, 1991·Toxicology Letters·S SardaşA E Karakaya
Apr 1, 1990·Scandinavian Journal of Work, Environment & Health·I StückerD Hémon
Dec 1, 1986·European Journal of Cancer & Clinical Oncology·S BenhamouB Festy
Nov 7, 1985·The New England Journal of Medicine·S G SelevanK Hemminki
Jul 1, 1981·Cancer Treatment Reports·H WaksvikA Brøgger
Jan 1, 1997·International Archives of Occupational and Environmental Health·A S EnsslinG Fruhmann
Feb 20, 2003·International Archives of Occupational and Environmental Health·Angelika PethranDennis Nowak
May 14, 2003·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Roberta TurciClaudio Minoia
Apr 3, 2004·The Annals of Occupational Hygiene·Wouter FransmanHans Kromhout
May 12, 2005·International Archives of Occupational and Environmental Health·Wouter FransmanHans Kromhout
Mar 6, 2007·The Annals of Occupational Hygiene·Wouter FransmanHans Kromhout
Nov 13, 2008·Journal of Veterinary Internal Medicine·K M RassnickK Autio
Jan 28, 2010·Journal of Veterinary Internal Medicine·A KnoblochD Simon
May 19, 2010·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·Cristina SottaniClaudio Minoia

❮ Previous
Next ❯

Citations

Nov 19, 2011·Journal of Veterinary Internal Medicine·E J ArnoldD W Knapp
Sep 2, 2014·The Veterinary Clinics of North America. Small Animal Practice·Shawna Klahn
Jan 28, 2010·Journal of Veterinary Internal Medicine·A KnoblochD Simon
Jul 31, 2013·Journal of Veterinary Internal Medicine·A P ThéonW D Wilson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.