Drug resistance and DNA repair

Cancer Metastasis Reviews
M Fox, J J Roberts

Abstract

DNA repair confers resistance to anticancer drugs which kill cells by reacting with DNA. A review of our current information on the topic will be presented here. Our understanding of the molecular biology of repair of 0(6)-alkylguanine adducts in DNA has advanced as a result of the molecular cloning of the E. coli ada gene but the precise role of this lesion in the cytotoxic effects of alkylating agents in mammalian cells is not completely understood. Less progress has been made in understanding the enzymology and molecular biology of DNA cross-link repair even though such lesions are important for the cytotoxic effects of the widely used bifunctional alkylating agents and platinum compounds. It is evident that drug sensitive or resistant phenotypes are as highly complex as are the effects of DNA damage on cell metabolism and various aspects of these effects are discussed. Few clear correlations have been made between quantitative differences in DNA repair capacity and cellular sensitivity but assays which were developed to measure fidelity and intragenomic heterogeneity in DNA repair are beginning to be applied. Such studies may reveal subtle differences between sensitive and resistant cell lines. The molecular cloning of huma...Continue Reading

References

Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·R M BakerL A Spencer
Aug 1, 1986·Molecular and Cellular Biology·P A Jeggo, R Holliday
Apr 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·R T SchimkeR N Johnston
Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·V A BohrP C Hanawalt
Jul 1, 1986·International Journal of Radiation Biology and Related Studies in Physics, Chemistry, and Medicine·J Thacker
Sep 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J Brennand, G P Margison
Oct 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R SagerC T Grabowy
Sep 1, 1985·Somatic Cell and Molecular Genetics·G L WeinbergD W Martin
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·B DempleT Lindahl
Jan 1, 1985·Biochimica Et Biophysica Acta·A L Pinto, S J Lippard
Dec 17, 1985·Biochimica Et Biophysica Acta·R SaffhillP J O'Connor
Dec 31, 1985·Chemico-biological Interactions·W T Briscoe, L E Cotter
Oct 1, 1985·Environmental Health Perspectives·W J BodellM L Rosenblum

❮ Previous
Next ❯

Citations

Oct 1, 1991·Journal of Neuro-oncology·M J Allalunis-TurnerR C Urtasun
Nov 1, 1990·Mutation Research·L den EngelseE Scherer
Dec 1, 1991·Pharmacology & Therapeutics·K J ScanlonT Funato
Feb 26, 2003·Cancer Detection and Prevention·Boyko S AtanassovGeorge C Russev
May 25, 2007·European Journal of Human Genetics : EJHG·Yuanchun LiYi Xie
Mar 16, 2000·Journal of the National Cancer Institute·Q WeiB Levin
Jan 1, 1991·The British Journal of Radiology·K D BagshaweR B Pedley
Dec 1, 1990·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·J R Masters
Jul 28, 2016·Tuberculosis·Amandeep SinghNagasuma Chandra
Jun 12, 2012·The Journal of Organic Chemistry·Abhigna PolavarapuMu-Hyun Baik
Jan 1, 1991·Acta Oncologica·P Borst
Mar 19, 2020·Journal of Biomedical Science·Chia-Yu GuhHsueh-Ping Chu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.

Related Papers

Annals of Oncology : Official Journal of the European Society for Medical Oncology
R K BurtV A Bohr
Journal of the National Cancer Institute
S G Chaney, Aziz Sancar
© 2021 Meta ULC. All rights reserved