Drug-resistance in Mycobacterium tuberculosis in Castilla y León, Spain, 2001-2005: third collaborative study

Enfermedades infecciosas y microbiología clínica
Armando Alberte-CastiñeirasPilar Pérez-Pascual

Abstract

During 2001-2005, a regional anti-tuberculosis drug resistance survey was conducted in Castilla y León, Spain, in newly treated HIV negative tuberculosis (TB) patients. A total of 918 Mycobacterium tuberculosis strains were studied (one strain per patient) from six hospitals corresponding to 46.7% of the total population of Castilla y León, using the proportion method on solid medium. Primary drug resistance was 4.2% (streptomycin 1.2%, isoniazid 3.2%, rifampin 0.3%, ethambutol 0.1% and pyrazinamide 0.5%). Mono-resistance was observed in 24 (2.6%) and resistance to both isoniazid and rifampin (multi-drug resistance) was detected in one case (0.1%). These results were not statistically significant compared to previous studies in the same Community. The incidence of primary drug resistance in the surveyed area was low, including isoniazid, allowing new anti-tuberculosis treatment with the standardised three-drug regimen to be started. Regular surveillance of drug resistance is recommended by the TB control programme in representative patient populations to optimize treatment regimens.

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Citations

Mar 22, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·M J van der WerfP Zucs
Sep 25, 2012·Enfermedades infecciosas y microbiología clínica·Francisco Múñiz-GonzálezOctavio Rivero-Lezcano
Jan 15, 2017·Enfermedades infecciosas y microbiología clínica·Ramiro López-MedranoIsabel Antolín-Ayala
Mar 14, 2014·The Pediatric Infectious Disease Journal·Begoña SantiagoUNKNOWN EREMITA Study Group
Apr 3, 2018·Microbial Drug Resistance : MDR : Mechanisms, Epidemiology, and Disease·Juan Bautista Gutiérrez-ArocaManuel Casal

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