Abstract
The aims were to determine the importance of p53 and bcl-2 expression on the response to chemotherapy with alkylating agents in patients with ovarian cancer. We have followed the response to chemotherapy in a series of 59 patients with ovarian adenocarcinoma designated as p53 and bcl-2 positive or negative by immunocytochemistry. Of these cases, 50 received either cisplatin + treosulfan or treosulfan alone. Immunocytochemistry for p53 was positive in 28/59 tumors. Patients were grouped according to their response to chemotherapy (stable or progressive disease) assessed at 6, 12, and 18 months. There was increasing divergence of p53+ and p53- tumors over time. Of those which were p53+, 25% showed progression at 6 months, 80% at 12 months and 89% progression at 18 months. In contrast, 23%, 50%, and 67% of p53- tumors showed progression at 6, 12 and 18 months respectively. For bcl-2, in 23/55 positive tumors there was progression in 35%, 78% and 94% compared with 25%, 57% and 59% in bcl-2 negative tumors at 6,12 and 18 months respectively. Those tumors which were bcl-2 and p53 negative were most likely to progress, while those which were bcl-2 and p53 positive had the best prognosis. These differences did not translate into increa...Continue Reading
References
Sep 18, 1992·Cell·L R LivingstoneT D Tlsty
Jul 2, 1992·Nature·D P Lane
Nov 1, 1995·British Journal of Cancer·R HenriksenK Oberg
Apr 8, 1995·Lancet·G R Skuse, J W Ludlow
May 6, 1995·Lancet·A MakrisC Allred
May 6, 1995·Lancet·G P Rice, G C Ebers
Jun 1, 1995·Obstetrics and Gynecology·L J HavrileskyA Berchuck
Jan 1, 1995·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A G van der ZeeE G de Vries
Mar 15, 1995·Cancer·M A LevesqueE P Diamandis
May 1, 1994·Annals of Oncology : Official Journal of the European Society for Medical Oncology·B NathanR Gelber
Nov 1, 1994·British Journal of Cancer·P J SmithN M Bleehen
Dec 1, 1994·International Journal of Cancer. Journal International Du Cancer·J M GeeR I Nicholson
Nov 4, 1994·Science·S W LoweT Jacks
Dec 1, 1994·British Journal of Cancer·K NiwaT Tamaya
Dec 16, 1994·Science·L H Hartwell, M B Kastan
Feb 28, 1994·Biochemical and Biophysical Research Communications·R D PettyP E Andreotti
Nov 1, 1993·Human Pathology·S BosariG Coggi
Oct 21, 1993·International Journal of Cancer. Journal International Du Cancer·R BrownS B Kaye
Apr 29, 1993·Nature·S W LoweT Jacks
Apr 29, 1993·Nature·A R ClarkeA H Wyllie
Nov 1, 1995·The Journal of Pathology·S P Dowell, P A Hall
Nov 1, 1995·The Journal of Pathology·T PietiläinenK Syrjänen
Mar 1, 1996·American Journal of Clinical Pathology·J DieboldU Löhrs
Mar 15, 1997·Lancet·A N Shelling
May 1, 1997·Annals of Oncology : Official Journal of the European Society for Medical Oncology·G VialeG Gasparini
Aug 22, 1997·International Journal of Cancer. Journal International Du Cancer·Y DongP G Parsons
Sep 23, 1997·Gynecologic Oncology·J P GeislerG A Miller
Sep 23, 1997·Gynecologic Oncology·F YamasakiH Sugimori
Jul 1, 1997·Anti-cancer Drugs·I A Cree, C M Kurbacher
Jan 1, 1997·Journal of Cancer Research and Clinical Oncology·P RöhlkeT Löning
Feb 14, 1998·Nature Medicine·B JansenH Pehamberger
Citations
Sep 19, 2012·Proceedings of the National Academy of Sciences of the United States of America·Shili XuNouri Neamati
Sep 18, 2003·Gynecologic Oncology·David Spriggs
Nov 5, 2003·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Richard von GeorgiKarsten Münstedt
Oct 15, 2009·Oncogene·M SzajnikT L Whiteside
Sep 26, 2013·International Journal of Molecular Sciences·Pavla BrachovaKimberly K Leslie
Apr 8, 2015·Mutation Research·Nicola Di Santo, Jessie Ehrisman
Apr 19, 2013·Journal of Cancer Research and Clinical Oncology·Linjuan XuZehua Wang
Feb 26, 2000·The Journal of Investigative Dermatology·G LiV C Ho
May 24, 2001·Gynecologic Oncology·M CuelloS Lipkowitz
Mar 1, 2017·ACS Applied Materials & Interfaces·Hongzhang DengZhihai Qin
Sep 27, 2000·The Journal of Pathology·K SatherleyI A Cree
Jul 31, 2001·International Journal of Cancer. Journal International Du Cancer·H HelmbachD Schadendorf
Oct 6, 2007·International Journal of Cancer. Journal International Du Cancer·Michael FraserBenjamin K Tsang
May 2, 2003·Annals of the New York Academy of Sciences·Susan H WeiTim H-M Huang
Aug 17, 2005·Medical Principles and Practice : International Journal of the Kuwait University, Health Science Centre·Y A Luqmani
Nov 8, 2005·Biological & Pharmaceutical Bulletin·Jian HuangTakashi Ikejima
Apr 26, 2012·Journal of Molecular Cell Biology·Jin Woo ChoiSunghoon Kim
Nov 10, 2013·Cancers·Nicola Di Santo, Jessie Ehrisman
Sep 12, 2019·Communications Biology·Nusrat J EpsiAntonina Mitrofanova
Apr 23, 2020·Indian Journal of Pathology & Microbiology·Nihad Abdul Razak AmanullahLetha Vilasiniamma
Mar 27, 1999·Journal of Women's Health
Apr 28, 2019·Toxins·Okiemute Rosa Johnson-AjinwoWen-Wu Li
Jun 29, 2005·Molekuliarnaia biologiia·V I TarasenkoIu M Konstantinov
Jul 25, 2019·Marine Drugs·Ga-Bin ParkDaejin Kim
Mar 29, 2013·Molecular Cancer Therapeutics·Shili XuNouri Neamati
Dec 3, 2005·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Nicole ConcinRobert Zeillinger
Jan 12, 2020·Communications Biology·Nusrat J EpsiAntonina Mitrofanova