Feb 1, 1977

Drug resistance in relation to use of silver sulphadiazine cream in a burns unit

Journal of Clinical Pathology
K Bridges, E J L LOWBURY

Abstract

Topical chemoprophylaxis of extensive burns with silver sulphadiazine cream led to a large increase in the proportion of sulphadiazine-resistant Gram-negative bacilli in a burns unit. When all sulphonamide treatment in the ward was stopped; the incidence of sulphonamide-resistant strains fell back to levels similar to those recorded when silver sulphadiazine treatment was introduced. This was associated with a large reduction in the incidence of resistance of certain Gram-negative bacilli (especially Klebstella sp) to several antibiotics. Transferable resistance to sulphadiazine, shown by conjugation experiments with Escherichia coli K12, was found in a majority of the strains of Klebsiella sp tested, and in other species. A pattern of transferable resistance to tetracycline, cephaloridine, chloramphenicol, ampicillin, carbenicillin, and sulphadiazine (T Ce Cl A Ca S) was found in four of the 22 strains of Klebsiella tested, and closely related patterns were transferred by five other strains. These patterns of resistance were commonly found in Klebsiella sp isolated from burns in the period before the withdrawal of sulphonamides from the ward but were found in none of the Klebsiella strains isolated in the first six months afte...Continue Reading

  • References10
  • Citations23

Citations

Mentioned in this Paper

Tetracycline Antibiotics
Antibiotic Resistance, Microbial
Tetracyclines
Dermazin
Conjugation
Sulfadiazine
Alkalescens-Dispar Group
Gentamicins
Antibiotic throat preparations
Antifungal Antibiotics, Topical

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