PMID: 321478Feb 1, 1977Paper

Drug resistance in relation to use of silver sulphadiazine cream in a burns unit

Journal of Clinical Pathology
K Bridges, E J Lowbury

Abstract

Topical chemoprophylaxis of extensive burns with silver sulphadiazine cream led to a large increase in the proportion of sulphadiazine-resistant Gram-negative bacilli in a burns unit. When all sulphonamide treatment in the ward was stopped; the incidence of sulphonamide-resistant strains fell back to levels similar to those recorded when silver sulphadiazine treatment was introduced. This was associated with a large reduction in the incidence of resistance of certain Gram-negative bacilli (especially Klebstella sp) to several antibiotics. Transferable resistance to sulphadiazine, shown by conjugation experiments with Escherichia coli K12, was found in a majority of the strains of Klebsiella sp tested, and in other species. A pattern of transferable resistance to tetracycline, cephaloridine, chloramphenicol, ampicillin, carbenicillin, and sulphadiazine (T Ce Cl A Ca S) was found in four of the 22 strains of Klebsiella tested, and closely related patterns were transferred by five other strains. These patterns of resistance were commonly found in Klebsiella sp isolated from burns in the period before the withdrawal of sulphonamides from the ward but were found in none of the Klebsiella strains isolated in the first six months afte...Continue Reading

References

Nov 20, 1971·Lancet·E J LowburyP M Ford
Feb 1, 1972·Journal of Clinical Pathology·E Roe, E J Lowbury
Nov 26, 1966·British Medical Journal·J S CasonC R Ricketts
Sep 1, 1970·Annals of Surgery·R P HummelW A Altemeier
Jan 13, 1951·Lancet·E TOPLEYL HURST

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Citations

Feb 1, 1985·Burns, Including Thermal Injury·X W WangJ W Davies
Feb 1, 1988·Burns, Including Thermal Injury·R H MilnerC A Reid
May 4, 2002·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Anne O Summers
Feb 17, 1979·British Medical Journal·K BridgesM D Wilkins
Aug 16, 2011·Nanomedicine : Nanotechnology, Biology, and Medicine·Oliver BrandtGeorg Stingl
Sep 16, 2008·Burns : Journal of the International Society for Burn Injuries·Fatih UygurErsin Ulkür
Jun 1, 1980·The Journal of Hospital Infection·G A Ayliffe
Dec 1, 1981·Journal of Clinical and Hospital Pharmacy·R M Richards, G N Mahlangu
Sep 1, 1985·The Journal of Hospital Infection·A P Gillett
Aug 30, 2012·Critical Reviews in Microbiology·Jean-Yves Maillard, Philippe Hartemann
Mar 10, 2015·Burns : Journal of the International Society for Burn Injuries·Joseph HardwickeNaiem Moiemen
Feb 1, 1992·Burns : Journal of the International Society for Burn Injuries·R Herruzo-CabreraM J Vizcaino-Alcaide
Jul 1, 1989·Clinics in Dermatology·W Winkelman, D Gratton
Jan 1, 1982·Burns, Including Thermal Injury·S P PeggH M Tahir
Apr 1, 1988·Critical Care Clinics·M C Robson
Jan 1, 1980·American Journal of Medical Genetics·M HigurashiK Yoneyama
Jan 1, 1983·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·H J ZenkerE Marré
Aug 13, 2002·British Journal of Nursing : BJN·G Castledine
Jan 1, 1979·Scandinavian Journal of Plastic and Reconstructive Surgery·S P PeggM Laundy
Jun 6, 2002·British Journal of Community Nursing·Caroline Dowsett
Jan 9, 1999·Clinical Microbiology Reviews·G McDonnell, A D Russell
Jan 23, 1988·Lancet·R Finch
Dec 10, 1990·Clinical Materials·A NangiaH Maibach
Aug 1, 1987·Burns, Including Thermal Injury·S D GeX T Jiang
Apr 21, 2018·Microbiology Spectrum·Jean-Yves Maillard

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