Drug resistance-related mutations in multidrug-resistant Mycobacterium tuberculosis isolates from diverse geographical regions

International Journal of Mycobacteriology
Senia Rosales-KlintzSven Hoffner

Abstract

Drug resistance in Mycobacterium tuberculosis is associated with chromosomal mutations in selected genes. These mutations can be screened for an early warning system for drug-resistant tuberculosis. The prevalence of individual mutations differs geographically, which must be considered in developing globally applicable screening tests. In order to analyse the geographical distribution and frequency of mutations conferring resistance to rifampicin, isoniazid and fluoroquinolones, the researchers investigated the presence of mutations in the rpoB gene, the katG gene, the mabA-inhA promoter region and the gyrA gene in clinical isolates of multidrug-resistant tuberculosis (MDR-TB) from Belarus, China, Iran/Iraq, Honduras, Romania and Uganda. For each study site, the researchers described the distribution of specific mutations in 20 clinical MDR-isolates. The distribution of resistance-related mutations varied significantly between the study sites. Settings with a high incidence of MDR-TB, such as Belarus, showed a narrower spectrum of mutations related to rifampicin and isoniazid resistance and also a higher prevalence of fluoroquinolone resistance than study sites with a lower MDR-TB prevalence. This study confirms that there are ...Continue Reading

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Citations

Dec 1, 2013·International Journal of Mycobacteriology·Sven Erik Hoffner
Jun 7, 2014·International Journal of Mycobacteriology·N ShubladzeN Bablishvili
Jun 1, 2017·International Journal of Mycobacteriology·Salima QamarRumina Hasan
May 17, 2017·Antimicrobial Agents and Chemotherapy·Natasha Van't Boveneind-VrubleuskayaJan-Willem C Alffenaar
Mar 11, 2021·Infection, Genetics and Evolution : Journal of Molecular Epidemiology and Evolutionary Genetics in Infectious Diseases·Akshatha Prasanna, Vidya Niranjan
Aug 20, 2021·Scientific Reports·Ayma AftabMuhammad Idrees

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