Drug-Resistant Aspergillus flavus Is Highly Prevalent in the Environment of Vietnam: A New Challenge for the Management of Aspergillosis?

Journal of Fungi
Tra My N DuongJustin Beardsley

Abstract

The burden of aspergillosis, especially Chronic Pulmonary Aspergillosis, is increasingly recognized, and the increasing presence of azole-resistant environmental Aspergillus fumigatus has been highlighted as a health risk. However, a sizable minority of aspergillosis is caused by Aspergillus flavus, which is assumed to be sensitive to azoles but is infrequently included in surveillance. We conducted environmental sampling at 150 locations in a rural province of southern Vietnam. A. flavus isolates were identified morphologically, their identity was confirmed by sequencing of the beta-tubulin gene, and then they were tested for susceptibility to azoles and amphotericin B according to EUCAST methodologies. We found that over 85% of A. flavus isolates were resistant to at least one azole, and half of them were resistant to itraconazole. This unexpectedly high prevalence of resistance demands further investigation to determine whether it is linked to agricultural azole use, as has been described for A. fumigatus. Clinical correlation is required, so that guidelines can be adjusted to take this information into account.

References

Apr 1, 1995·Applied and Environmental Microbiology·N L Glass, G C Donaldson
Apr 9, 1999·Clinical Microbiology Reviews·J P Latgé
May 29, 2007·Microbiology·M T HedayatiD W Denning
Feb 12, 2009·Mycoses·Suganthini KrishnanPranatharthi H Chandrasekar
Nov 21, 2009·The Lancet Infectious Diseases·Paul E VerweijWillem J G Melchers
Oct 18, 2011·Emerging Infectious Diseases·Jan W M van der LindenPaul E Verweij
Oct 27, 2011·The Journal of Antimicrobial Chemotherapy·Anuradha ChowdharyJacques F Meis
May 9, 2012·Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases·Maiken C ArendrupUNKNOWN EUCAST-AFST
Jan 22, 2013·Antimicrobial Agents and Chemotherapy·Sarah S GonçalvesArnaldo L Colombo
Oct 3, 2013·The Journal of Antimicrobial Chemotherapy·Anuradha ChowdharyJacques F Meis
Apr 5, 2014·Euro Surveillance : Bulletin Européen Sur Les Maladies Transmissibles = European Communicable Disease Bulletin·A PrigitanoA M Tortorano
Jul 10, 2014·The Journal of Antimicrobial Chemotherapy·Anuradha ChowdharyJacques F Meis
Dec 11, 2014·Studies in Mycology·R A SamsonJ C Frisvad
May 6, 2015·Antimicrobial Agents and Chemotherapy·Oliver BaderUwe Groß
Sep 25, 2016·Medical Mycology·Marut TangwattanachuleepornOliver Bader
Mar 8, 2017·Antimicrobial Agents and Chemotherapy·Mojtaba Taghizadeh-ArmakiSeyedmojtaba Seyedmousavi
Nov 25, 2017·The Brazilian Journal of Infectious Diseases : an Official Publication of the Brazilian Society of Infectious Diseases·Laura Bedin DenardiSydney Hartz Alves
Jan 27, 2018·Journal of Fungi·Felix BongominDavid W Denning
Jun 27, 2019·Antimicrobial Agents and Chemotherapy·Thomas R SewellMatthew C Fisher

❮ Previous
Next ❯

Citations

Aug 24, 2021·Environmental Microbiology·Norman van Rhijn, David W Denning

❮ Previous
Next ❯

Software Mentioned

Sensititre

Related Concepts

Related Feeds

Aspergillosis

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.

Aspergillosis (ASM)

Aspergillosis is the name given to a wide variety of diseases caused by infection by fungi of the genus Aspergillus. Aspergillosis occurs in chronic or acute forms which are clinically very distinct. Most cases of acute aspergillosis occur in patients with severely compromised immune systems. Chronic colonization or infection can cause complications in people with underlying respiratory illnesses. Discover the latest research on aspergillosis here.