Drug-resistant epilepsy: From multiple hypotheses to an integral explanation using preclinical resources.

Epilepsy & Behavior : E&B
Daniel Pérez-PérezLuisa Rocha

Abstract

Drug-resistant epilepsy affects approximately one-third of the patients with epilepsy. The pharmacoresistant condition in epilepsy is mainly explained by six hypotheses. In addition, several experimental models have been used to understand the mechanisms involved in pharmacoresistant epilepsy and to identify novel therapies to control this condition. However, the global prevalence of this disease persists without changes. Several factors can explain this situation. First of all, the pharmacoresistant epilepsy is explained by different and independent hypotheses. Each hypothesis indicates specific mechanisms to explain the drug-resistant condition in epilepsy. However, there are different findings suggesting common mechanisms between the different hypotheses. Other important situation is that the experimental models designed for the screening of drugs with potential anticonvulsant effect do not consider factors such as age, gender, type of epilepsy, and comorbid disorders. The present review focuses on indicating the limitations for each hypothesis and the relationships among them. The relevance to consider central and peripheral phenomena associated with the drug-resistant condition in different types of epilepsy is also indica...Continue Reading

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Citations

Nov 30, 2019·Journal of Inherited Metabolic Disease·Zeinab Wehbe, Sara Tucci
Jun 19, 2020·Annual Review of Biomedical Data Science·Rion Brattig CorreiaLuis M Rocha
Nov 26, 2020·Epilepsy & Behavior : E&B·Álvaro Gutiérrez-ViedmaIrene García-Morales
Feb 25, 2021·Journal of Pharmaceutical and Biomedical Analysis·Andreia CaronaAna Fortuna
Mar 9, 2021·Epilepsia Open·Simela ChatzikonstantinouDimitrios Kazis
Mar 30, 2021·Epilepsy Research·Mohammad AlsumailiFaisal Alotaibi
Jul 22, 2021·Annals of Neurology·Cenglin XuZhong Chen

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