Drug-resistant M leprae

Clinics in Dermatology
Paul Saunderson

Abstract

Dapsone was used as a single drug to treat leprosy, and secondary resistance soon developed, greatly reducing its effectiveness. Multidrug therapy has been used successfully since 1982, and until now, only a few sporadic cases of rifampicin resistance have been reported. Surveillance is needed to make sure that chemotherapy for leprosy remains effective for the foreseeable future. This review is based on reports from the annual drug resistance surveillance meetings convened by the World Health Organization and related literature. Very few cases of rifampicin resistance are currently known globally, except for a small group of cases in a former leprosy colony in Brazil. A low level of ofloxacin resistance has been found, especially in India. A larger number of patient samples should be tested each year. The results give grounds for cautious optimism, although the number of samples tested should be significantly increased. Possible foci of rifampicin resistance near former leprosy colonies in Brazil should be further investigated.

References

Jun 1, 1977·Leprosy Review·J M PearsonR J Rees
Mar 10, 2001·Nature·S T ColeB G Barrell
Dec 4, 2001·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Emmanuelle CambauVincent Jarlier
Jun 8, 2007·Emerging Infectious Diseases·N Sarita ShahJ Peter Cegielski
Dec 18, 2010·Future Microbiology·Pushpendra Singh, Stewart T Cole

❮ Previous
Next ❯

Citations

Jan 17, 2016·Clinics in Dermatology·Andrzej Grzybowski, Marcos Virmond
Oct 6, 2016·PLoS Neglected Tropical Diseases·Camilo Beltrán-AlzateNora Cardona-Castro
Mar 15, 2019·Emerging Microbes & Infections·Vaishali P WamanTom L Blundell
Apr 29, 2020·Antimicrobial Agents and Chemotherapy·Charlotte AvanziMilton Ozório Moraes
Dec 17, 2020·Pharmaceutics·Luíse L ChavesSalette Reis

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimicrobial Resistance (ASM)

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.

Antimicrobial Resistance

Antimicrobial resistance poses a significant threat to the continued successful use of antimicrobial agents for the treatment of bacterial infections.