Drug-resistant parietal epilepsy: polymorphic ictal semiology does not preclude good post-surgical outcome

Epileptic Disorders : International Epilepsy Journal with Videotape
Stefano FrancioneGiorgio Lo Russo

Abstract

We investigated the anatomo-electro-clinical features and clinical outcome of surgical resections strictly confined to the parietal lobe in 40 consecutive patients who received surgery for pharmacoresistant seizures. The population was subcategorized into a paediatric (11 subjects; mean age at surgery: 7.2+/-3.7 years) and an adult group (29 patients; mean age at surgery: 30+/-10.8 years). The paediatric group more frequently exhibited personal antecedents, neurological impairment, high seizure frequency, and dysplastic lesions. Nonetheless, compared with adults, children had better outcome and more frequently reached definitive drug discontinuation after surgery. After a mean follow-up of 9.4 years (range: 3.1-16.7), 30 subjects (75%) were classified as Engel Class I. The presence of multiple types of aura in the same patient, as well as a high incidence of secondary generalization, represented a characteristic feature of parietal seizures and did not correlate negatively with surgical outcome. A total resection of the epileptogenic zone and a localizing/regional interictal EEG were statistically significant predictive factors of outcome. Intracerebral investigation, performed in 55% of cases, contributed to complete tailored ...Continue Reading

Citations

Oct 5, 2019·Neurology. Clinical Practice·Jafar Mehvari HabibabadiSamden Lhatoo
Jul 20, 2016·Expert Opinion on Drug Metabolism & Toxicology·Sven C van DijkmanOscar Della Pasqua
May 25, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Sami AunoJ Matias Palva
Jul 21, 2021·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Davide FontiFabrice Bartolomei
Aug 19, 2021·Practical Neurology·Fahmida A ChowdhuryMatthew C Walker

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