Drug-resistant Trypanosoma congolense in naturally infected donkeys in north Omo Zone, southern Ethiopia

Veterinary Parasitology
E Assefa, G Abebe

Abstract

A three-part study was conducted to determine the efficacy of isometamidium chloride in donkey populations naturally infected with trypanosomes in north Omo Zone, southern Ethiopia. In the first, 373 randomly selected donkeys from four villages were examined for trypanosome infections by the dark ground/phase contrast buffy coat technique (BCT) in November 1999. The trypanosome prevalence was 18.2% (95% confidence interval (CI): 14.4, 22.5) and Trypanosoma congolense was the most common species accounting for 66.2% of the overall infections. In the second part, 40 infected donkeys were selected and treated with a prophylactic dose of 1.0mg/kg of isometamidium chloride and thereafter monitored every 14 days for 90 days. Trypanosomes were detected in eight donkeys within 1 month and in 20 donkeys within 2 months of treatment. About 16% (5/32) of donkeys infected with T. congolense were detected parasitemic 1 month after treatment. In addition, the result also revealed that all relapse/breakthrough infections were due to T. congolense. In the third part of this study mice were infected with two T. congolense field isolates from donkeys that were found to be parasitemic within 1 or 2 months after isometamidium treatment. The mice w...Continue Reading

References

Jan 1, 1977·Transactions of the Royal Society of Tropical Medicine and Hygiene·M MurrayW I McIntyre
Nov 1, 1974·Tropical Animal Health and Production·J M Scott, R G Pegram

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Citations

Jan 16, 2010·Animal Health Research Reviews·Daniel Ndzingu Awa, Mbunkah Daniel Achukwi
Mar 17, 2006·Parasitology Research·Yohannes AfeworkPeter-Henning Clausen
Dec 3, 2014·The Veterinary Clinics of North America. Equine Practice·Andrew P Stringer

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