Abstract
This multi-center, retrospective study aimed to clarify retention rates and reasons for discontinuation of 7 biological disease-modifying antirheumatic drugs (bDMARDs) and tofacitinib (TOF), one of the janus kinase inhibitors, in bDMARDs-naïve and bDMARDs-switched patients with rheumatoid arthritis (RA). This study assessed 3897 patients and 4415 treatment courses with bDMARDs and TOF from 2001 to 2019 (2737 bDMARDs-naïve courses and 1678 bDMARDs-switched courses [59.5% of switched courses were their second agent], female 82.3%, baseline age 57.4 years, disease duration 8.5 years; rheumatoid factor positivity 78.4%; Disease Activity Score in 28 joints using erythrocyte sedimentation rate 4.3; concomitant prednisolone [PSL] dose 6.1 mg/day [usage 42.4%], and methotrexate [MTX] dose 8.5 mg/week [usage 60.9%]). Treatment courses included abatacept (ABT; n = 663), adalimumab (ADA; n = 536), certolizumab pegol (CZP; n = 226), etanercept (ETN; n = 856), golimumab (GLM; n = 458), infliximab (IFX; n = 724), tocilizumab (TCZ; n = 851), and TOF (n = 101/only bDMARDs-switched cases). Drug discontinuation reasons (categorized into lack of effectiveness, toxic adverse events, non-toxic reasons, or remission) and rates were estimated at 36 m...Continue Reading
References
Mar 1, 1988·Arthritis and Rheumatism·F C ArnettH S Luthra
Jan 11, 2005·Annals of the Rheumatic Diseases·E HjardemUNKNOWN Danish Database for Biological Therapies in Rheumatology Study Group
Jun 15, 2007·Bone Marrow Transplantation·L ScruccaF Aversa
Mar 20, 2009·Annals of the Rheumatic Diseases·G JonesM C Genovese
May 1, 2009·Arthritis and Rheumatism·Sophie Martin Du PanUNKNOWN Swiss Clinical Quality Management Physicians
Dec 30, 2009·Arthritis and Rheumatism·Merete Lund HetlandUNKNOWN All Departments of Rheumatology in Denmark
Jul 31, 2010·Rheumatology·Kimme L HyrichUNKNOWN British Society for Rheumatology Biologics Register (BSRBR)
Aug 12, 2010·Annals of the Rheumatic Diseases·Daniel AletahaGillian Hawker
Nov 19, 2010·Rheumatology·Julia F SimardJohan Askling
May 10, 2011·Annals of the Rheumatic Diseases·Henrik Christian LeffersUNKNOWN all departments of rheumatology in Denmark
Feb 2, 2012·Annals of the Rheumatic Diseases·Jeffrey D GreenbergUNKNOWN CORRONA Investigators
Feb 2, 2012·Annals of the Rheumatic Diseases·Sophie Martin Du PanAxel Finckh
Dec 5, 2012·Bone Marrow Transplantation·Y Kanda
Mar 9, 2013·Scandinavian Journal of Rheumatology·Y HishitaniA Kumanogoh
Nov 29, 2013·Annals of the Rheumatic Diseases·M NeoviusUNKNOWN ARTIS Study Group
Apr 15, 2014·Rheumatology·Ennio Giulio FavalliPier Luigi Meroni
Dec 17, 2014·Rheumatology·Helena Forsblad-d'EliaLennart T H Jacobsson
Feb 18, 2015·Nature Reviews. Rheumatology·Josef S Smolen, Daniel Aletaha
Apr 30, 2015·Rheumatology·Cem GabayUNKNOWN SCQM collaborating physicians
Sep 1, 2015·Arthritis & Rheumatology·Huifeng YunJeffrey R Curtis
Nov 12, 2015·Arthritis Care & Research·Ennio Giulio FavalliPier Luigi Meroni
Dec 23, 2015·International Journal of Rheumatic Diseases·Young Ho Lee, Sang-Cheol Bae
Nov 28, 2016·Clinical Therapeutics·Maria-Cecilia VieiraGene V Wallenstein
Dec 3, 2016·Arthritis Research & Therapy·Leslie R HarroldJoel M Kremer
Jan 27, 2017·RMD Open·Meghna JaniKimme L Hyrich
Jan 27, 2017·RMD Open·Chihiro TakahashiTsutomu Takeuchi
Mar 8, 2017·Annals of the Rheumatic Diseases·Josef S SmolenDésirée van der Heijde
Mar 17, 2017·Annals of the Rheumatic Diseases·Sofia RamiroRobert B M Landewé
Feb 10, 2018·Seminars in Arthritis and Rheumatism·Carlos Fernández-DíazRicardo Blanco
Mar 16, 2018·PloS One·Kosuke EbinaHideki Yoshikawa
Aug 4, 2018·Drugs -- Real World Outcomes·Rosarin SruamsiriJörg Mahlich
Aug 5, 2018·Arthritis Research & Therapy·Motomu HashimotoTsuneyo Mimori
Oct 14, 2018·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·Almut Dutz, Steffen Löck
Apr 12, 2019·Arthritis Research & Therapy·Kosuke EbinaHideki Yoshikawa
May 9, 2019·PloS One·Kosuke EbinaHideki Yoshikawa
Oct 18, 2019·Rheumatology International·Koichi MurataShuichi Matsuda
Mar 13, 2020·Clinical Rheumatology·Kosuke EbinaMakoto Hirao
Citations
Jan 31, 2021·Clinical Rheumatology·Kosuke EbinaKen Nakata
Apr 28, 2021·Rheumatology International·Yuichi MaedaAtsushi Kumanogoh
Jun 18, 2021·Seminars in Arthritis and Rheumatism·Seulggie ChoiEun Young Lee
Jul 6, 2021·Therapeutic Advances in Musculoskeletal Disease·Jean-Guillaume LetarouillyJulien Paccou
Aug 6, 2021·Open Access Rheumatology : Research and Reviews·Ilaria Bertoldi, Roberto Caporali
Jul 25, 2021·Arthritis Research & Therapy·Naoki IwamotoAtsushi Kawakami
Aug 21, 2021·Biologics : Targets & Therapy·Kate E FindeisenAndrew J K Ostor
Sep 7, 2021·Rheumatology and Therapy·Elizabeth A HoldsworthDaniel E Furst
Dec 12, 2021·Modern Rheumatology·Kosuke Ebina
Jan 9, 2022·Scientific Reports·Kosuke EbinaKen Nakata