Drug safety in acute migraine treatment

Expert Opinion on Drug Safety
János TajtiLászló Vécsei

Abstract

A number of drugs are available for acute migraine treatment, but they are not all effective for all patients and all attacks. The safety profiles of migraine drugs limit their use in patients with certain comorbid conditions, and adverse effects may also reduce the level of patient compliance. The different types of acute migraine drugs are discussed, with particular regard to safety issues and potential adverse effects. The frequent use of analgesics, ergot alkaloids and triptans may result in the development of medication overuse headache (MOH). The initiation of a migraine attack is not fully understood, and therefore treatment aimed at causative factors is currently not available. The tolerability and adverse effects of the drugs available at present often limit their use. NSAIDs are frequently associated with gastrointestinal, and possibly also cardiovascular side effects. Ergot alkaloids may induce arterial vasoconstriction, while the administration of triptans is contraindicated in cardiovascular, cerebrovascular and peripheral vascular diseases. The frequent use of these drugs poses the risk of the development of MOH. There is a need for pathomechanism-based drugs, and for the future achievement of personalized medicine.

References

Mar 1, 1989·Cephalalgia : an International Journal of Headache·P G AnderssonP C Gøtzsche
Nov 1, 1989·Archives of Internal Medicine·L G Miller, J Jankovic
Sep 1, 1974·American Journal of Obstetrics and Gynecology·J M Shane, F Naftolin
Jun 1, 1984·Cephalalgia : an International Journal of Headache·P Tfelt-Hansen, J Olesen
Jul 1, 1995·Nature Medicine·C WeillerH C Diener
Apr 1, 1997·Clinical Pharmacokinetics·N M Davies, K E Anderson
Jun 23, 1999·Proceedings of the National Academy of Sciences of the United States of America·T D WarnerJ R Vane
Nov 23, 2000·The New England Journal of Medicine·C BombardierUNKNOWN VIGOR Study Group
Feb 13, 2001·Cephalalgia : an International Journal of Headache·P Tfelt-HansenUNKNOWN International Headache Society Clinical Trials Subcommittee
Sep 5, 2001·Pediatrics·UNKNOWN American Academy of Pediatrics Committee on Drugs
Jan 25, 2002·The New England Journal of Medicine·Peter J GoadsbyMichel D Ferrari
May 16, 2002·Headache·E Anne MacGregorPaul T G Davies
May 25, 2002·Headache·Alan RapoportCharlotte Keywood
Jul 9, 2002·Cephalalgia : an International Journal of Headache·A V Krymchantowski, J S Barbosa
Aug 9, 2003·Expert Opinion on Drug Safety·Stewart J Tepper, David Millson
Aug 20, 2005·Headache·Timothy R SmithW James Alexander

❮ Previous
Next ❯

Citations

Jan 12, 2017·Expert Opinion on Investigational Drugs·Matilde CapiMartina Curto
Dec 12, 2017·Expert Opinion on Drug Metabolism & Toxicology·Abimael González-HernándezCarlos M Villalón
Sep 11, 2018·Expert Opinion on Pharmacotherapy·László VécseiJános Tajti
Feb 14, 2020·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Antonio SantoroAndrea Fontana
Jun 1, 2018·Current Medicinal Chemistry·Laszlo VécseiLars Edvinsson
Oct 29, 2020·Expert Review of Neurotherapeutics·Enrique Martínez-PíasÁngel L Guerrero
Apr 19, 2020·Journal of the American Association of Nurse Practitioners·Theresa Mallick-Searle, Maureen Moriarty
Jun 24, 2021·Headache·Jessica AilaniUNKNOWN Board of Directors of the American Headache Society
Apr 30, 2020·ACS Chemical Neuroscience·Swapnil RautPallab Bhattacharya

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.