PMID: 3767255Jan 1, 1986Paper

Drug screening: evaluation of the Toxi-Lab TLC system

Annals of Clinical Biochemistry
D R Jarvie, D Simpson

Abstract

An evaluation of a commercial TLC Kit System (Toxi-Lab) is described. The performance of the system is assessed in the detection of drugs in overdose and in therapy, and is compared with a GC drug screening system. Toxi-Lab performed well in investigating drug overdoses. We found data on metabolite patterns essential for the identification of drugs in urine and for this reason the system performed much better than GC screening in which information on metabolites is limited. In our experience Toxi-Lab screening was not sufficiently sensitive for the detection of commonly prescribed psychiatric drugs taken in therapeutic doses. This system is rapid, versatile and suitable for small laboratories, but is comparatively expensive and some expertise is necessary to interpret results. A major deficiency of the kit is that the identification procedures are designed for the detection of drugs available in the USA and many drugs prescribed in the UK have been omitted.

References

Feb 4, 1976·Journal of Chromatography·D H NeiderhiserH P Roth
May 1, 1974·Journal of Chromatographic Science·B S FinkleD M Taylor
Mar 1, 1984·Annals of Clinical Biochemistry·D R Jarvie, D Simpson
Feb 7, 1981·The Medical Journal of Australia·R W Bury, M L Mashford
May 1, 1981·Clinical Toxicology·M B NicotraM W Noall

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Citations

Sep 4, 2012·Clinics in Laboratory Medicine·Donald L Frederick, Michael G Bissell
Jun 15, 1988·Analytical Chemistry·J Sherma
Jan 1, 1996·Annals of Clinical Biochemistry·N R Badcock, G D Zoanetti
Nov 1, 1988·Annals of Clinical Biochemistry·S Dawling, B Widdop
Mar 1, 1987·Annals of Clinical Biochemistry·S NadkarniA Hay
Mar 1, 1989·Annals of Clinical Biochemistry·D SimpsonR Heyworth
Nov 1, 1994·Annals of Clinical Biochemistry·N R Badcock, G D Zoanetti
May 8, 1992·Journal of Chromatography·R N Gupta
Sep 1, 1990·Annals of Clinical Biochemistry·S DawlingB Widdop
Sep 1, 1990·Annals of Clinical Biochemistry·K WolffA W Hay

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