Drug states as modulators of conditioned immobility in a latent discrimination procedure

European Journal of Pharmacology
J H R MaesJ M H Vossen

Abstract

Midazolam, amphetamine, and flesinoxan were used in four rat experiments to examine the usefulness of a latent Pavlovian discrimination procedure to assess the discriminative-stimulus, or occasion-setting, properties of drugs. Experiment 1 first assessed the unconditioned effect of each of the drugs on the dependent measure used, which was immobility. Relative to saline, midazolam enhanced immobility, whereas flesinoxan, and especially amphetamine decreased it. In each of the Experiments 2-4, subjects received a limited number of training sessions during which they consistently received a footshock in a distinctive box after a drug but not after saline, or vice versa. Subsequently, non-reinforced test sessions were performed in the drug and saline states in both the conditioning box and a novel box. Relative to the saline state, rats previously shocked under midazolam were less mobile in the conditioning box under midazolam, whereas rats previously not shocked under amphetamine or flesinoxan were more mobile under the drug. The remaining animals did not show differential responding. The response profiles were accounted for in terms of the combined operation of an associative, or occasion-setting, effect and a non-associative ef...Continue Reading

References

Dec 1, 1992·Pharmacology, Biochemistry, and Behavior·W A CorrigallB A Lodge
Apr 1, 1992·Journal of Experimental Psychology. Animal Behavior Processes·T L DavidsonL E Jarrard
Jan 1, 1990·Journal of Experimental Psychology. Animal Behavior Processes·G M MartinD van der Kooy
Jan 1, 1987·Psychological Review·J M Pearce
Feb 19, 1982·European Journal of Pharmacology·F C Colpaert, P A Janssen
Aug 1, 1994·Pharmacology, Biochemistry, and Behavior·R J RodgersA Davies
Apr 1, 1994·Pharmacology, Biochemistry, and Behavior·C E YbemaB Olivier
Nov 1, 1991·Behavioural Pharmacology·J.P. DruhanA.G. Phillips

Related Concepts

Flesinoxan
Amphetamines
Metazoa
Behavior, Animal
Conditioned Reflex
Discrimination (Process of Differentiation)
Versed
Piperazines
Rats, Wistar
Rats, Laboratory

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