Drug survival of anti-tumour necrosis factor α therapy in spondyloarthropathies: results from the Spanish emAR II Study

Rheumatology
José Luis Rosales-AlexanderCésar Magro-Checa

Abstract

To assess drug survival and the reasons for switching anti-TNF-α therapy in SpA patients in a Spanish nationwide study. A cross-sectional study was performed. Sample size was calculated to represent all regions and hospitals throughout the country. Demographic data, patient characteristics and disease activity parameters were obtained. Drug survival and reasons for switching anti-TNF therapy were also recorded. A total of 467 SpA patients receiving at least one anti-TNF agent were identified. Among patients who received a first, second and third anti-TNF course, 39.4%, 37.4% and 23.1% discontinued treatment, respectively. The main reasons for switching anti-TNF agents in the first course were lack or loss of efficacy (LOE) and adverse events (AEs) in 40% and 30% of switchers, respectively. Similarly, reasons for switching during the second anti-TNF course were LOE in 48% and AEs in 28% of switchers. Of the 467 SpA patients starting anti-TNF therapy, 28% switched to a second and 8% switched to a third therapy. Mean drug survival for the first, second and third anti-TNF courses were 84.4 (95% CI 78.4, 90.5), 70.2 (95% CI 61.6, 78.9) and 64.8 (95% CI 51.1, 78.5) months, respectively (P = 0.315). Twenty-eight per cent of SpA patien...Continue Reading

References

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Citations

Aug 20, 2016·Rheumatology International·R Lopez-GonzalezUNKNOWN emAR II Study Group
Nov 11, 2017·Arthritis Care & Research·Mansour AlazmiNigil Haroon
Jul 18, 2017·The Journal of Rheumatology·Sebastián E Ibáñez VodnizzaIrene E van der Horst-Bruinsma
Jun 12, 2020·Therapeutic Advances in Gastroenterology·Sheila D RustgiShailja C Shah

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