Drug survival of cyclosporine in the treatment of hand eczema: a multicentre, daily use study

Journal of the European Academy of Dermatology and Venereology : JEADV
W A ChristoffersM L A Schuttelaar

Abstract

Hand eczema is a common condition; it is often chronic and can be difficult to treat. Cyclosporine is used off-label to treat severe hand eczema; however, the evidence for this treatment is scarce. To examine the drug survival of cyclosporine in a daily practice cohort of patients with chronic hand eczema. This retrospective daily use study included hand eczema patients who were treated with cyclosporine between 01-06-1999 and 01-06-2014 in two Dutch university hospitals. Patient and treatment characteristics were retrospectively collected from medical charts. First treatment episodes were analysed by means of Kaplan-Meier drug survival curves. Possible determinants of drug survival were analysed by Cox regression models. Treatment effectiveness was analysed with a retrospective physician's global assessment. A total of 102 patients were treated with cyclosporine. The median drug survival rate was 0.86 years (10.3 months). The overall drug survival rate after 6 months, 1, 2 and 3 years were 61.7%, 45.2%, 18.6% and 13.9% respectively. Main reasons for discontinuation were adverse events, especially early in treatment, and ineffectiveness. After 3 months, a good response to treatment was recorded in 62.9% of the patients. Cyclosp...Continue Reading

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Citations

Jan 30, 2019·Dermatologic Therapy·Griffin R LeeVivian Y Shi
Jun 26, 2015·The British Journal of Dermatology·K PolitiekM L A Schuttelaar
Sep 14, 2019·Der Hautarzt; Zeitschrift für Dermatologie, Venerologie, und verwandte Gebiete·E Berthold, E Weisshaar
Aug 11, 2020·The Australasian Journal of Dermatology·Marius RademakerLi-Chuen Wong
Jan 8, 2021·Therapeutics and Clinical Risk Management·Celina DubinEmma Guttman-Yassky
Mar 22, 2020·Actas dermo-sifiliográficas·J F Silvestre SalvadorA M Giménez-Arnau

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