Drug Susceptibility of 33 Reference Strains of Slowly Growing Mycobacteria to 19 Antimicrobial Agents

BioMed Research International
Hui PangKanglin Wan

Abstract

Objectives . Slowly growing mycobacteria (SGM) are prevalent worldwide and cause an extensive spectrum of diseases.Methods. In this study, the antimicrobial susceptibility of 33 reference strains of SGM to 19 antimicrobial agents was tested using a modified microdilution method.Results. Cefmetazole (32/33) and azithromycin (32/33) exhibited the highest antimicrobial activity, and dapsone (9/33) exhibited the lowest activity against the tested strains. Cefoxitin (30/33), cefoperazone (28/33), and cefepime (28/33) were effective against a high proportion of strains, and macrolides were also highly effective as well as offering the benefit of convenient oral administration to patients. Linezolid (27/33), meropenem (26/33), sulfamethoxazole (26/33), and tigecycline (25/33) showed the highest activity; clofazimine (20/33) and doxycycline (18/33) showed intermediate activity; and rifapentine (13/33), rifabutin (13/33), and minocycline (11/33) showed low antimicrobial activity, closely followed by thioacetazone (10/33) and pasiniazid (10/33), against the tested organisms. According to their susceptibility profiles, the slowly growing speciesMycobacterium aviumandMycobacterium simiaewere the least susceptible to the tested drugs, where...Continue Reading

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Citations

May 14, 2020·Journal of Wildlife Diseases·Justice Opare OdoiTetsuo Asai
Feb 24, 2021·Antimicrobial Agents and Chemotherapy·Bettina SchulthessPeter Sander

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