Drug susceptibility pattern of Helicobacter pylori in patients with dyspepsia at the Kenyatta National Hospital, Nairobi

East African Medical Journal
L Lwai-LumeS Kariuki

Abstract

To determine drug susceptibility pattern of Helicobacter pylori to metronidazole, clarithromycin, amoxicillin and tetracycline in patients presenting with dyspepsia at the Kenyatta National Hospital. Cross-sectional descriptive study. Kenyatta National Hospital, Nairobi. Two hundred and sixty-seven patients aged 15 to 85 years, presenting with dyspepsia and referred for upper gastro-intestinal endoscopy were recruited into the study. Between October 2003 and April 2004, 138 male and 129 female patients aged 15-85 years, with a mean age of 45.4 years were studied. Gastritis was the most common endoscopic finding, occurring in 55%, followed by normal-looking mucosa in 27% and peptic ulcer disease in 16% of the patients. The rapid urease test was positive in 184 patients (69%). The culture yield was 62% of these CLO (Campylobacter like organisms) positive biopsies. The MIC90 (minimum inhibitory concentration) was 256 mg/l for metronidazole, 1.5 mg/l for clarithromycin, 1.5 mg/l for tetracycline and 0.75 mg/l for amoxicillin. The MIC values for amoxicillin were significantly higher in the female patients (p = 0.02) but showed no significant variation for age. The MIC values for metronidazole, tetracycline and clarithromycin showed ...Continue Reading

Citations

Jan 29, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jordan M WinterChristine A Iacobuzio-Donahue
Jul 11, 2019·BMC Infectious Diseases·Frederick K WangaiR Andrew Seaton
Jul 25, 2019·World Journal of Gastroenterology : WJG·Stella SmithRinaldo Pellicano

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