Drug susceptibility testing of slowly growing non-tuberculous mycobacteria using slomyco test-system

PloS One
Vitalii LitvinovS G Safonova

Abstract

The objective of the research was to assess the susceptibility of the slowly growing nontuberculous mycobacteria strains to the antimicrobial drugs used for mycobaterioses treatment using SLOMYCO test system. We assessed 363 NTM strains: 177 MAC (161 M. avium, 16 M. intracellulare), 112 M. kansasii and 74 M. xenopi collected from the respiratory material of the patients were under the treatment or under diagnostic procedures at our Center, affiliates and the diagnostic department in 2010-2016. Drug sucseptibility for NTM was tested using the Sensititre SLOWMYCO system (TREK DIAGNOSTIC Systems Ltd., UK). MICs were established by microdilutions in Mueller-Hinton broth on polystyrene 96-well plates. The statistical analysis was done using the StatGraphics Plus 5.0 software. The data were compared pairwise using Pearson χ2 test with Yates correction. 95% confidence interval (CI) were calculated. Statistically significant differences were considered for p <0.05. Log-rank test and Kaplan-Meier curves were used to assess the concentration-dependent surveillance probability. The statistically significant differences were revealed in sensitivity/resistance isolates of M. avium and M. intracellulare: M. avium strains were resistant to hi...Continue Reading

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Citations

Jun 21, 2019·Current Pharmaceutical Design·Prasad MinakshiGaya Prasad
Mar 7, 2020·Frontiers in Microbiology·Jérémy JaffréUNKNOWN CNR-MyRMA (Centre National de Référence des Mycobactéries et de la Résistance des Mycobactéries aux Antituberculeux)
Feb 20, 2021·Scientific Reports·Komal Umashankar RaoGabriela Godaly
Mar 23, 2021·Clinical Pharmacokinetics·Jan-Willem AlffenaarCharles A Peloquin
Apr 14, 2021·Indian Journal of Medical Microbiology·Megha SharmaShreya Khandelwal
Oct 21, 2021·Journal of Medical Microbiology·Vitaly LitvinovJulia Mikhailova

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Software Mentioned

SLOMYCO
SLOMYCO Sensititre
RAPMYCO
StatGraphics Plus

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