Drug target gene-based analyses of drug repositionability in rare and intractable diseases.

Scientific Reports
Ryuichi Sakate, Tomonori Kimura

Abstract

Drug development for rare and intractable diseases has been challenging for decades due to the low prevalence and insufficient information on these diseases. Drug repositioning is increasingly being used as a promising option in drug development. We aimed to analyze the trend of drug repositioning and inter-disease drug repositionability among rare and intractable diseases. We created a list of rare and intractable diseases based on the designated diseases in Japan. Drug information extracted from clinical trial data were integrated with information of drug target genes, which represent the mechanism of drug action. We obtained 753 drugs and 551 drug target genes from 8307 clinical trials for 189 diseases or disease groups. Trend analysis of drug sharing between a disease pair revealed that 1676 drug repositioning events occurred in 4401 disease pairs. A score, Rgene, was invented to investigate the proportion of drug target genes shared between a disease pair. Annual changes of Rgene corresponded to the trend of drug repositioning and predicted drug repositioning events occurring within a year or two. Drug target gene-based analyses well visualized the drug repositioning landscape. This approach facilitates drug development fo...Continue Reading

References

Dec 11, 1999·Nucleic Acids Research·M Kanehisa, S Goto
Dec 31, 2005·Nucleic Acids Research·David S WishartJennifer Woolsey
May 16, 2007·Proceedings of the National Academy of Sciences of the United States of America·Kwang-Il GohAlbert-László Barabási
Mar 31, 2012·Nature Reviews. Drug Discovery·Irena Melnikova
Apr 29, 2016·PLoS Computational Biology·Raul Rodriguez-Esteban
Mar 16, 2017·Scientific Data·Adam S Brown, Chirag J Patel
Jun 6, 2018·Current Clinical Pharmacology·Ryuichi SakateAkifumi Matsuyama
Sep 19, 2019·European Journal of Human Genetics : EJHG·Stéphanie Nguengang WakapAna Rath

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