Drug-Target Interactions: Prediction Methods and Applications

Current Protein & Peptide Science
Shanmugam AnusuyaM Michael Gromiha

Abstract

Identifying the interactions between drugs and target proteins is a key step in drug discovery. This not only aids to understand the disease mechanism, but also helps to identify unexpected therapeutic activity or adverse side effects of drugs. Hence, drug-target interaction prediction becomes an essential tool in the field of drug repurposing. The availability of heterogeneous biological data on known drug-target interactions enabled many researchers to develop various computational methods to decipher unknown drug-target interactions. This review provides an overview on these computational methods for predicting drug-target interactions along with available webservers and databases for drug-target interactions. Further, the applicability of drug-target interactions in various diseases for identifying lead compounds has been outlined.

Citations

Nov 12, 2019·Frontiers in Cellular Neuroscience·Anna V LeopoldVladislav V Verkhusha
Jan 14, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·A ToliosT Mohr

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