Nov 20, 2016

Drug targeting of heme proteins in Mycobacterium tuberculosis

Drug Discovery Today
Kirsty J McLean, Andrew W Munro

Abstract

TB, caused by the human pathogen Mycobacterium tuberculosis (Mtb), causes more deaths than any other infectious disease. Iron is crucial for Mtb to infect the host and to sustain infection, with Mtb encoding large numbers of iron-binding proteins. Many of these are hemoproteins with key roles, including defense against oxidative stress, cellular signaling and regulation, host cholesterol metabolism, and respiratory processes. Various heme enzymes in Mtb are validated drug targets and/or products of genes essential for bacterial viability or survival in the host. Here, we review the structure, function, and druggability of key Mtb heme enzymes and strategies used for their inhibition.

  • References1
  • Citations3

Mentioned in this Paper

Bacterial Proteins
Cholesterol Metabolic Process
Tuberculosis
Genes
Enzymes, antithrombotic
Regulation of Biological Process
Pathogenic Organism
Respiratory Process
Mtb8.4 protein, Mycobacterium tuberculosis
Oxidative Stress

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