PMID: 9535166Apr 16, 1998Paper

Drug targeting via retrometabolic approaches

Pharmacology & Therapeutics
N S Bodor, Peter Buchwald

Abstract

Retrometabolic approaches incorporate targeting and metabolic considerations into the drug design process and represent a novel, systematic methodology for the design of safe, localized compounds. Two major design concepts aimed to increase the therapeutic index of drugs were developed. Chemical delivery systems allow targeting of active biological molecules to specific target sites or organs, based on predictable enzymatic activation. Soft drug approaches are used to design new drugs by building in the molecule, in addition to the activity, the most desired way in which the molecule is to be deactivated and detoxified subsequent to exerting its biological effects. Many examples are provided; related computer programs are also briefly discussed.

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Citations

Jun 6, 2000·Advanced Drug Delivery Reviews·N Bodor, P Buchwald
Jan 26, 2008·Nature Reviews. Drug Discovery·Jarkko RautioJouko Savolainen
Nov 8, 2001·SAR and QSAR in Environmental Research·E Pop, P Buchwald
May 1, 2008·The AAPS Journal·Jarkko RautioJouko Savolainen
Jan 15, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Giovanni TosiAndreas M Grabrucker
Oct 16, 1999·Journal of Controlled Release : Official Journal of the Controlled Release Society·N Bodor
Feb 15, 2011·Expert Opinion on Drug Delivery·Shadab MdJaved Ali
Jul 1, 2007·Expert Opinion on Drug Discovery·Peter Buchwald
Jun 23, 2012·International Journal of Pharmaceutics·Daniela AllhennAlf Lamprecht
Aug 28, 2014·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Yashumati Ratan BhardwajDharma Kishore
Jul 22, 2016·Expert Opinion on Drug Delivery·Pranjal TaskarSoumyajit Majumdar
May 26, 2017·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Rami Walid ChakrounHonggang Cui
Jun 6, 2003·Seminars in Pediatric Neurology·Michael R Pranzatelli
Jan 5, 2002·Journal of Receptor and Signal Transduction Research·N Bodor, P Buchwald
Sep 13, 2013·Journal of Environmental Science and Health. Part C, Environmental Carcinogenesis & Ecotoxicology Reviews·Almas IqbalMohammad A Kamal

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