Drug targets for resistant malaria: Historic to future perspectives

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Sahil KumarRajesh K Singh

Abstract

New antimalarial targets are the prime need for the discovery of potent drug candidates. In order to fulfill this objective, antimalarial drug researches are focusing on promising targets in order to develop new drug candidates. Basic metabolism and biochemical process in the malaria parasite, i.e. Plasmodium falciparum can play an indispensable role in the identification of these targets. But, the emergence of resistance to antimalarial drugs is an escalating comprehensive problem with the progress of antimalarial drug development. The development of resistance has highlighted the need for the search of novel antimalarial molecules. The pharmaceutical industries are committed to new drug development due to the global recognition of this life threatening resistance to the currently available antimalarial therapy. The recent developments in the understanding of parasite biology are exhilarating this resistance issue which is further being ignited by malaria genome project. With this background of information, this review was aimed to highlights and provides useful information on various present and promising treatment approaches for resistant malaria, new progresses, pursued by some innovative targets that have been explored til...Continue Reading

References

Apr 1, 1992·Antimicrobial Agents and Chemotherapy·P K RathodR D Young
Jun 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·N Surolia, G Padmanaban
Feb 1, 1994·Antimicrobial Agents and Chemotherapy·G M DaviesR G Wilson
Aug 16, 1996·Journal of Molecular Biology·R J WilsonD H Williamson
Aug 29, 1997·The Journal of Biological Chemistry·Z Q BondayG Padmanaban
Aug 7, 1998·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·C Ruwende, A Hill
Oct 3, 1998·Antimicrobial Agents and Chemotherapy·S M GanttP Sinnis
Oct 15, 1998·Proceedings of the National Academy of Sciences of the United States of America·R F WallerG I McFadden
Dec 31, 1998·Antimicrobial Agents and Chemotherapy·G A McConkey
Apr 23, 1999·Journal of Medicinal Chemistry·T S HaqueJ A Ellman
Dec 11, 1999·Molecular and Biochemical Parasitology·D SyafruddinS Marzuki
Mar 17, 2000·Science·J Drews
Apr 5, 2000·Nature·S PagolaS K Madsen
Mar 29, 2001·Physiological Reviews·K Kirk
Jul 4, 2001·European Journal of Biochemistry·D L JackM H Saier
Aug 22, 2001·Chemistry & Biology·A F Kisselev, A L Goldberg
Sep 12, 2001·Molecular and Biochemical Parasitology·C S GaviganA Bell
Oct 10, 2001·Progress in Lipid Research·R J HeathC O Rock
Dec 1, 2001·The Journal of Biological Chemistry·Martin HansenEric Beitz
Dec 26, 2001·Biochimica Et Biophysica Acta·G G van DoorenG I McFadden
Jan 5, 2002·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·S A RalphG I McFadden
Jan 10, 2002·Proceedings of the National Academy of Sciences of the United States of America·Ritu BanerjeeDaniel E Goldberg
Jan 30, 2002·Molecular and Biochemical Parasitology·Louisa McRobert, Glenn A McConkey
Feb 13, 2002·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·David S RoosBoris Striepen
Apr 12, 2002·Current Topics in Medicinal Chemistry·Junko OhkandaAndrew D Hamilton
May 30, 2002·The Biochemical Journal·Timothy J EganJason C Walden
Jul 18, 2002·Antimicrobial Agents and Chemotherapy·Bertrand Lell, Peter G Kremsner

❮ Previous
Next ❯

Citations

May 8, 2020·Future Medicinal Chemistry·Ishan WadiAbhinav Sinha
Oct 9, 2019·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sijongesonke Peter, Blessing Atim Aderibigbe
May 27, 2020·Scientifica·Oluwole Solomon OladejiTokunbo Yemisi Afolabi
Oct 4, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Veronika R KarpinaLouis Maes
Nov 26, 2020·Molecular Microbiology·Manish KumarManoj T Duraisingh
Nov 19, 2020·Infection and Drug Resistance·Melkamu Adigo ShibeshiSeyfe Asrade Atnafie
Jan 29, 2021·European Journal of Medicinal Chemistry·Om P S PatelLesetja J Legoabe
Nov 19, 2020·Drug Design, Development and Therapy·Abdrrahman Shemsu SururKaleab Asres
Mar 27, 2021·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Min ZhouThomas Efferth
Dec 18, 2020·European Journal of Medicinal Chemistry·Om P S PatelLesetja J Legoabe
May 3, 2021·Protein Science : a Publication of the Protein Society·Vysakh K ViswanathAnirudha Lakshminarasimhan
Jun 16, 2021·Journal of Biomolecular Structure & Dynamics·Vivek K VyasManjunath Ghate
Nov 23, 2021·Frontiers in Microbiology·Leonardo Galindo-GonzálezStephen E Strelkov

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antimalarial Agents (ASM)

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Antimalarial Agents

Antimalarial agents, also known as antimalarials, are designed to prevent or cure malaria. Discover the latest research on antimalarial agents here.

Related Papers

Combinatorial Chemistry & High Throughput Screening
Mahesh A BarmadeMange Ram Yadav
Chemical Biology & Drug Design
Nitendra K SahuDharm Veer Kohli
Current Medicinal Chemistry
Anna Caroline AguiarRafael V C Guido
European Journal of Medicinal Chemistry
Ajay KumarDhirender Kaushik
© 2022 Meta ULC. All rights reserved